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Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury
It is often difficult to regain neurological function following spinal cord injury (SCI). Neuroinflammation is thought to be responsible for this failure. Regulating the inflammatory response post-SCI may contribute to the recovery of neurological function. Over the past few decades, studies have fo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751019/ https://www.ncbi.nlm.nih.gov/pubmed/36532022 http://dx.doi.org/10.3389/fimmu.2022.1014013 |
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author | Fu, Sheng-Ping Chen, Si-Yu Pang, Qi-Ming Zhang, Meng Wu, Xiang-Chong Wan, Xue Wan, Wei-Hong Ao, Jun Zhang, Tao |
author_facet | Fu, Sheng-Ping Chen, Si-Yu Pang, Qi-Ming Zhang, Meng Wu, Xiang-Chong Wan, Xue Wan, Wei-Hong Ao, Jun Zhang, Tao |
author_sort | Fu, Sheng-Ping |
collection | PubMed |
description | It is often difficult to regain neurological function following spinal cord injury (SCI). Neuroinflammation is thought to be responsible for this failure. Regulating the inflammatory response post-SCI may contribute to the recovery of neurological function. Over the past few decades, studies have found that macrophages/microglia are one of the primary effector cells in the inflammatory response following SCI. Growing evidence has documented that macrophages/microglia are plastic cells that can polarize in response to microenvironmental signals into M1 and M2 macrophages/microglia. M1 produces pro-inflammatory cytokines to induce inflammation and worsen tissue damage, while M2 has anti-inflammatory activities in wound healing and tissue regeneration. Recent studies have indicated that the transition from the M1 to the M2 phenotype of macrophage/microglia supports the regression of inflammation and tissue repair. Here, we will review the role of the inflammatory response and macrophages/microglia in SCI and repair. In addition, we will discuss potential molecular mechanisms that induce macrophage/microglia polarization, with emphasis on neuroprotective therapies that modulate macrophage/microglia polarization, which will provide new insights into therapeutic strategies for SCI. |
format | Online Article Text |
id | pubmed-9751019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97510192022-12-16 Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury Fu, Sheng-Ping Chen, Si-Yu Pang, Qi-Ming Zhang, Meng Wu, Xiang-Chong Wan, Xue Wan, Wei-Hong Ao, Jun Zhang, Tao Front Immunol Immunology It is often difficult to regain neurological function following spinal cord injury (SCI). Neuroinflammation is thought to be responsible for this failure. Regulating the inflammatory response post-SCI may contribute to the recovery of neurological function. Over the past few decades, studies have found that macrophages/microglia are one of the primary effector cells in the inflammatory response following SCI. Growing evidence has documented that macrophages/microglia are plastic cells that can polarize in response to microenvironmental signals into M1 and M2 macrophages/microglia. M1 produces pro-inflammatory cytokines to induce inflammation and worsen tissue damage, while M2 has anti-inflammatory activities in wound healing and tissue regeneration. Recent studies have indicated that the transition from the M1 to the M2 phenotype of macrophage/microglia supports the regression of inflammation and tissue repair. Here, we will review the role of the inflammatory response and macrophages/microglia in SCI and repair. In addition, we will discuss potential molecular mechanisms that induce macrophage/microglia polarization, with emphasis on neuroprotective therapies that modulate macrophage/microglia polarization, which will provide new insights into therapeutic strategies for SCI. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751019/ /pubmed/36532022 http://dx.doi.org/10.3389/fimmu.2022.1014013 Text en Copyright © 2022 Fu, Chen, Pang, Zhang, Wu, Wan, Wan, Ao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Fu, Sheng-Ping Chen, Si-Yu Pang, Qi-Ming Zhang, Meng Wu, Xiang-Chong Wan, Xue Wan, Wei-Hong Ao, Jun Zhang, Tao Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title | Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title_full | Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title_fullStr | Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title_full_unstemmed | Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title_short | Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
title_sort | advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751019/ https://www.ncbi.nlm.nih.gov/pubmed/36532022 http://dx.doi.org/10.3389/fimmu.2022.1014013 |
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