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Immune modulation after traumatic brain injury
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous syste...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751027/ https://www.ncbi.nlm.nih.gov/pubmed/36530909 http://dx.doi.org/10.3389/fmed.2022.995044 |
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author | Bouras, Marwan Asehnoune, Karim Roquilly, Antoine |
author_facet | Bouras, Marwan Asehnoune, Karim Roquilly, Antoine |
author_sort | Bouras, Marwan |
collection | PubMed |
description | Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous system, hormonal systems, and the regulation of immune cells. This physiological response induces an immunosuppression and tolerance state that promotes to the occurrence of secondary infections. This review describes the immunological consequences of TBI and highlights potential novel therapeutic approaches using immune modulation to restore homeostasis between the nervous system and innate immunity. |
format | Online Article Text |
id | pubmed-9751027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97510272022-12-16 Immune modulation after traumatic brain injury Bouras, Marwan Asehnoune, Karim Roquilly, Antoine Front Med (Lausanne) Medicine Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous system, hormonal systems, and the regulation of immune cells. This physiological response induces an immunosuppression and tolerance state that promotes to the occurrence of secondary infections. This review describes the immunological consequences of TBI and highlights potential novel therapeutic approaches using immune modulation to restore homeostasis between the nervous system and innate immunity. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751027/ /pubmed/36530909 http://dx.doi.org/10.3389/fmed.2022.995044 Text en Copyright © 2022 Bouras, Asehnoune and Roquilly. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bouras, Marwan Asehnoune, Karim Roquilly, Antoine Immune modulation after traumatic brain injury |
title | Immune modulation after traumatic brain injury |
title_full | Immune modulation after traumatic brain injury |
title_fullStr | Immune modulation after traumatic brain injury |
title_full_unstemmed | Immune modulation after traumatic brain injury |
title_short | Immune modulation after traumatic brain injury |
title_sort | immune modulation after traumatic brain injury |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751027/ https://www.ncbi.nlm.nih.gov/pubmed/36530909 http://dx.doi.org/10.3389/fmed.2022.995044 |
work_keys_str_mv | AT bourasmarwan immunemodulationaftertraumaticbraininjury AT asehnounekarim immunemodulationaftertraumaticbraininjury AT roquillyantoine immunemodulationaftertraumaticbraininjury |