Cargando…

Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: Post-hoc analyses of the phase II adrenomedullin and outcome in septic shock 2 trial

PURPOSE: Adrecizumab, a non-neutralizing antibody of adrenomedullin (ADM) was recently investigated regarding its potential to restore endothelial barrier function in septic shock patients with high plasma ADM levels. Circulating dipeptidyl peptidase 3 (cDPP3), a protease involved in the degradation...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Lier, Dirk, Picod, Adrien, Marx, Gernot, Laterre, Pierre-François, Hartmann, Oliver, Knothe, Claudia, Azibani, Feriel, Struck, Joachim, Santos, Karine, Zimmerman, Jens, Bergmann, Andreas, Mebazaa, Alexandre, Pickkers, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751049/ https://www.ncbi.nlm.nih.gov/pubmed/36530868 http://dx.doi.org/10.3389/fmed.2022.1058235

Ejemplares similares

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)
por: Geven, Christopher, et al.
Publicado: (2019)

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial
por: Laterre, Pierre-François, et al.
Publicado: (2021)

Adrecizumab, a non-neutralizing anti-adrenomedullin antibody, improves haemodynamics and attenuates myocardial oxidative stress in septic rats
por: Blet, Alice, et al.
Publicado: (2019)

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
por: Mebazaa, Alexandre, et al.
Publicado: (2018)

The mechanism of action of the adrenomedullin-binding antibody adrecizumab
por: Geven, Christopher, et al.
Publicado: (2018)

Significance of adrenomedullin and the role of adrecizumab in sepsis
por: Nair, Abhijit
Publicado: (2021)

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study
por: Hollinger, Alexa, et al.
Publicado: (2018)

Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness
por: Lundberg, Oscar H. M., et al.
Publicado: (2020)

Single pro-adrenomedullin determination in septic shock and 28-day mortality
por: Garcia-de la Torre, A, et al.
Publicado: (2014)

Adrenomedullin blockade improves catecholamine responsiveness and kidney function in resuscitated murine septic shock
por: Wagner, K, et al.
Publicado: (2012)

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock
por: Wagner, Katja, et al.
Publicado: (2013)

Septic Shock: Management and Outcomes
por: Basodan, Nojood, et al.
Publicado: (2022)

The Predictive Value of Adrenomedullin for Development of Severe Sepsis and Septic Shock in Emergency Department
por: Chen, Yun-Xia, et al.
Publicado: (2013)

Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients
por: Lundberg, Oscar H. M., et al.
Publicado: (2016)

Adrenomedullin: A Double-edged Sword in Septic Shock and Heart Failure Therapeutics?
por: Mehmood, Muddassir
Publicado: (2020)

Alteration of the Renin–Angiotensin–Aldosterone System in Shock: Role of the Dipeptidyl Peptidase 3
por: Picod, Adrien, et al.
Publicado: (2021)

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)
por: Karakas, Mahir, et al.
Publicado: (2020)

Outcome research in meningococcal septic shock
por: Buysse, Corinne, et al.
Publicado: (2008)

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU
por: Blet, Alice, et al.
Publicado: (2020)

Septic Shock Due to Candidemia: Outcomes and Predictors of Shock Development
por: Guzman, Jorge A, et al.
Publicado: (2011)

Diastolic shock index and clinical outcomes in patients with septic shock
por: Ospina-Tascón, Gustavo A., et al.
Publicado: (2020)

Septic Shock
por: Kim, Kyuseok, et al.
Publicado: (2018)

Reply to Mehmood: Adrenomedullin: A Double-edged Sword in Septic Shock and Heart Failure Therapeutics?
por: Lee, Warren L.
Publicado: (2020)

The outcomes of severe sepsis and septic shock in the UK
por: Reuben, Adam D, et al.
Publicado: (2006)

Outcome of septic shock in patients with malignancies and neutropenia
por: Furmanchuk, D
Publicado: (2005)

The path to great pediatric septic shock outcomes
por: Ames, Stefanie G., et al.
Publicado: (2018)

Hemodynamics effects of adrecizumab in sepsis rat
por: Blet, A, et al.
Publicado: (2015)

Association of Illness Severity With Family Outcomes Following Pediatric Septic Shock
por: Killien, Elizabeth Y., et al.
Publicado: (2022)

Managing septic shock
por: Gerlach, Herwig, et al.
Publicado: (2010)

Septic shock—an update
por: Kumar, Ashir
Publicado: (1982)

Outcome of septic shock patients with relative adrenal insufficiency
por: Friedman, G, et al.
Publicado: (2005)

Association of REL polymorphisms and outcome of patients with septic shock
por: Toubiana, Julie, et al.
Publicado: (2016)

Lactate clearance as the predictor of outcome in pediatric septic shock
por: Choudhary, Richa, et al.
Publicado: (2017)

Early intubation and patient-centered outcomes in septic shock
por: Qu, Jianmin, et al.
Publicado: (2022)

Circulating dipeptidyl peptidase 3 and bio-adrenomedullin levels are associated with impaired outcomes in critically ill COVID-19 patients: a prospective international multicentre study
por: van Lier, Dirk, et al.
Publicado: (2023)

Comparison of the clinical characteristics and clinical outcomes of culture-positive septic shock and culture-negative septic shock among pediatric patients
por: Kim, Da Hyun, et al.
Publicado: (2023)

Current use of vasopressors in septic shock
por: Scheeren, Thomas W. L., et al.
Publicado: (2019)

Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review
por: Önal, Uğur, et al.
Publicado: (2018)

Prediction of Impending Septic Shock in Children With Sepsis
por: Liu, Ran, et al.
Publicado: (2021)

Characteristics and outcomes of patients with culture negative septic shock compared with patients with culture positive septic shock: a retrospective cohort study
por: Kethireddy, Shravan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1md0cot7hvaamp0mrts9d2his9