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Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

It is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combi...

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Autores principales: Obaíd, Miguel L., Carvajal, Felipe, Camacho, Juan Pablo, Corrales-Orovio, Rocío, Martorell, Ximena, Varas, Juan, Calderón, Wilfredo, Guzmán, Christian Dani, Brenet, Marianne, Castro, Margarita, Orlandi, Cecilia, San Martín, Sebastián, Eblen-Zajjur, Antonio, Egaña, José Tomás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751053/
https://www.ncbi.nlm.nih.gov/pubmed/36532582
http://dx.doi.org/10.3389/fbioe.2022.1004155
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author Obaíd, Miguel L.
Carvajal, Felipe
Camacho, Juan Pablo
Corrales-Orovio, Rocío
Martorell, Ximena
Varas, Juan
Calderón, Wilfredo
Guzmán, Christian Dani
Brenet, Marianne
Castro, Margarita
Orlandi, Cecilia
San Martín, Sebastián
Eblen-Zajjur, Antonio
Egaña, José Tomás
author_facet Obaíd, Miguel L.
Carvajal, Felipe
Camacho, Juan Pablo
Corrales-Orovio, Rocío
Martorell, Ximena
Varas, Juan
Calderón, Wilfredo
Guzmán, Christian Dani
Brenet, Marianne
Castro, Margarita
Orlandi, Cecilia
San Martín, Sebastián
Eblen-Zajjur, Antonio
Egaña, José Tomás
author_sort Obaíd, Miguel L.
collection PubMed
description It is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combined with improved clinical procedures to promote wound oxygenation is an active field of research in regenerative medicine. This case report derives from a cohort of patients enrolled in a previously published ongoing phase I clinical trial (NCT03960164), to assess safety of photosynthetic scaffolds for the treatment of full skin defects. Here, we present a 56 year old patient, with a scar contracture in the cubital fossa, which impaired the elbow extension significantly affecting her quality of life. As part of the treatment, the scar contracture was removed, and the full-thickness wound generated was surgically covered with a photosynthetic scaffold for dermal regeneration, which was illuminated to promote local oxygen production. Then, in a second procedure, an autograft was implanted on top of the scaffold and the patient’s progress was followed for up to 17 months. Successful outcome of the whole procedure was measured as improvement in functionality, clinical appearance, and self-perception of the treated area. This case report underscores the long-term safety and applicability of photosynthetic scaffolds for dermal regeneration and their stable compatibility with other surgical procedures such as autograft application. Moreover, this report also shows the ability to further improve the clinical outcome of this procedure by means of dermal vacuum massage therapy and, more importantly, shows an overall long-term improvement in patient´s quality of life, supporting the translation of photosynthetic therapies into human patients.
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spelling pubmed-97510532022-12-16 Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration Obaíd, Miguel L. Carvajal, Felipe Camacho, Juan Pablo Corrales-Orovio, Rocío Martorell, Ximena Varas, Juan Calderón, Wilfredo Guzmán, Christian Dani Brenet, Marianne Castro, Margarita Orlandi, Cecilia San Martín, Sebastián Eblen-Zajjur, Antonio Egaña, José Tomás Front Bioeng Biotechnol Bioengineering and Biotechnology It is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combined with improved clinical procedures to promote wound oxygenation is an active field of research in regenerative medicine. This case report derives from a cohort of patients enrolled in a previously published ongoing phase I clinical trial (NCT03960164), to assess safety of photosynthetic scaffolds for the treatment of full skin defects. Here, we present a 56 year old patient, with a scar contracture in the cubital fossa, which impaired the elbow extension significantly affecting her quality of life. As part of the treatment, the scar contracture was removed, and the full-thickness wound generated was surgically covered with a photosynthetic scaffold for dermal regeneration, which was illuminated to promote local oxygen production. Then, in a second procedure, an autograft was implanted on top of the scaffold and the patient’s progress was followed for up to 17 months. Successful outcome of the whole procedure was measured as improvement in functionality, clinical appearance, and self-perception of the treated area. This case report underscores the long-term safety and applicability of photosynthetic scaffolds for dermal regeneration and their stable compatibility with other surgical procedures such as autograft application. Moreover, this report also shows the ability to further improve the clinical outcome of this procedure by means of dermal vacuum massage therapy and, more importantly, shows an overall long-term improvement in patient´s quality of life, supporting the translation of photosynthetic therapies into human patients. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751053/ /pubmed/36532582 http://dx.doi.org/10.3389/fbioe.2022.1004155 Text en Copyright © 2022 Obaíd, Carvajal, Camacho, Corrales-Orovio, Martorell, Varas, Calderón, Guzmán, Brenet, Castro, Orlandi, San Martín, Eblen-Zajjur and Egaña. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Obaíd, Miguel L.
Carvajal, Felipe
Camacho, Juan Pablo
Corrales-Orovio, Rocío
Martorell, Ximena
Varas, Juan
Calderón, Wilfredo
Guzmán, Christian Dani
Brenet, Marianne
Castro, Margarita
Orlandi, Cecilia
San Martín, Sebastián
Eblen-Zajjur, Antonio
Egaña, José Tomás
Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title_full Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title_fullStr Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title_full_unstemmed Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title_short Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
title_sort case report: long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751053/
https://www.ncbi.nlm.nih.gov/pubmed/36532582
http://dx.doi.org/10.3389/fbioe.2022.1004155
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