Cargando…

Comprehensive serum metabolomics and network analysis to reveal the mechanism of gypenosides in treating lung cancer and enhancing the pharmacological effects of cisplatin

Gypenosides (GYP) exerted anticancer activity against various cancers. However, the mechanism of GYP against lung cancer (LC) in vivo remains unclear. This study aims to reveal the potential mechanism of GYP against LC and enhancing cisplatin efficacy using a comprehensive analysis of metabolomics,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Yan-Shuang, Xiao, Man-Yu, Xie, Peng, Xie, Jin-Bo, Guo, Mei, Li, Fang-Fang, Piao, Xiang-Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751056/ https://www.ncbi.nlm.nih.gov/pubmed/36532716 http://dx.doi.org/10.3389/fphar.2022.1070948

Ejemplares similares

Gypenoside L and Gypenoside LI Inhibit Proliferation in Renal Cell Carcinoma via Regulation of the MAPK and Arachidonic Acid Metabolism Pathways
por: Liu, Hui, et al.
Publicado: (2022)

Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling
por: Hu, Yonghong, et al.
Publicado: (2022)

Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice
por: Xie, Jin-Bo, et al.
Publicado: (2023)

The mechanism of Renshen-Fuzi herb pair for treating heart failure—Integrating a cardiovascular pharmacological assessment with serum metabolomics
por: Chen, Xiaofei, et al.
Publicado: (2022)

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway
por: Liu, Suqing, et al.
Publicado: (2022)

Practical Protocol for Comprehensively Evaluating Sulfur-Fumigation of Baizhi Based on Metabolomics, Pharmacology, and Cytotoxicity
por: Deng, Ai-Ping, et al.
Publicado: (2022)

Integrated analysis of comprehensive metabolomics and network pharmacology to reveal the mechanisms of abelmoschus manihot (L.) medik. in the treatment of cisplatin-induced chronic kidney disease
por: Liao, Jian-Cheng, et al.
Publicado: (2022)

Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Kangfuxiaoyan Suppository for Treating Chronic Pelvic Inflammatory Disease
por: Zhang, Zhengyi, et al.
Publicado: (2022)

Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome
por: Duan, Yanfen, et al.
Publicado: (2021)

Research on the Potential Mechanism of Gypenosides on Treating Thyroid-Associated Ophthalmopathy Based on Network Pharmacology
por: Li, Kaijun, et al.
Publicado: (2019)

Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction
por: Pan, Boyu, et al.
Publicado: (2022)

Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome
por: Zhang, Wensen, et al.
Publicado: (2022)

Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data
por: Song, Ya-Nan, et al.
Publicado: (2017)

Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo
por: Yu, Haijie, et al.
Publicado: (2016)

Integrated Serum Pharmacochemistry, Metabolomics, and Network Pharmacology to Reveal the Material Basis and Mechanism of Danggui Shaoyao San in the Treatment of Primary Dysmenorrhea
por: Xiong, Hui, et al.
Publicado: (2022)

Integrating Network Pharmacology and Metabolomics to Elucidate the Mechanism of Action of Huang Qin Decoction for Treament of Diabetic Liver Injury
por: Xu, Xiaomin, et al.
Publicado: (2022)

Serum Metabolomics Coupling With Clinical Laboratory Indicators Reveal Taxonomic Features of Leukemia
por: Xiong, Hao-, et al.
Publicado: (2022)

Combined metabolomics and network pharmacology to elucidate the mechanisms of Dracorhodin Perchlorate in treating diabetic foot ulcer rats
por: Deng, Pin, et al.
Publicado: (2022)

Role of Licochalcone A in Potential Pharmacological Therapy: A Review
por: Li, Meng-Ting, et al.
Publicado: (2022)

A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications
por: Wen, Min, et al.
Publicado: (2022)

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia
por: Pang, Han-Qing, et al.
Publicado: (2018)

Determination of Gypenoside A and Gypenoside XLIX in Rat Plasma by UPLC-MS/MS and Applied to the Pharmacokinetics and Bioavailability
por: He, Yan, et al.
Publicado: (2022)

Prediction of the mechanism for the combination of diallyl trisulfide and cisplatin against gastric cancer: a network pharmacology study and pharmacological evaluation
por: Lv, Huaiyou, et al.
Publicado: (2023)

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease
por: Xie, Jinghui, et al.
Publicado: (2023)

Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling
por: Cao, Li-Hua, et al.
Publicado: (2022)

Wenshenyang recipe treats infertility through hormonal regulation and inflammatory responses revealed by transcriptome analysis and network pharmacology
por: Xie, Lan, et al.
Publicado: (2022)

Integrating Constituents Absorbed into Blood, Network Pharmacology, and Quantitative Analysis to Reveal the Active Components in Rubus chingii var. suavissimus that Regulate Lipid Metabolism Disorder
por: Jiang, Man-jing, et al.
Publicado: (2021)

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
por: Xie, Long, et al.
Publicado: (2023)

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics
por: Qu, Shu-Yue, et al.
Publicado: (2021)

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient
por: Sun, Hao, et al.
Publicado: (2016)

Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet
por: Shan, Jinjun, et al.
Publicado: (2018)

Integrated Metabolomics and Network Pharmacology Analysis Immunomodulatory Mechanisms of Qifenggubiao Granules
por: Guo, Bindan, et al.
Publicado: (2022)

Chuanxiong improves angiogenesis via the PI3K/AKT/Ras/MAPK pathway based on network pharmacology and DESI-MSI metabolomics
por: Cheng, Xue-hao, et al.
Publicado: (2023)

Comprehensive metabolomics and lipidomics profiling uncovering neuroprotective effects of Ginkgo biloba L. leaf extract on Alzheimer’s disease
por: Liu, Li-Wei, et al.
Publicado: (2022)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice
por: Cui, Binbin, et al.
Publicado: (2022)

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
por: Luo, Wen, et al.
Publicado: (2021)

Based on network pharmacology and molecular docking to explore the protective effect of Epimedii Folium extract on cisplatin-induced intestinal injury in mice
por: Xia, Juan, et al.
Publicado: (2022)

The pharmacological mechanism of Chinese herbs effective in treating advanced ovarian cancer: Integrated meta-analysis and network pharmacology analysis
por: Yang, Ze, et al.
Publicado: (2022)

An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats
por: Shi, Peiying, et al.
Publicado: (2020)

Metabolomic profiling combined with network analysis of serum pharmacochemistry to reveal the therapeutic mechanism of Ardisiae Japonicae Herba against acute lung injury
por: Han, Xiao-Xiao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5o91snc9i3ktmfv903uu1ggbh3