A pan-cancer analysis of the FAT1 in human tumors

FAT atypical cadherin 1 (FAT1) is one of the most mutagenic genes in tumors, and several critical studies have revealed its role in tumors, although no pan-cancer studies are currently available. Therefore, we explored the potential oncogenic role of FAT1 in 33 tumors based on The Cancer Genome Atlas and Gene Expression Omibus datasets. We found that FAT1 was strongly expressed in most tumors and significantly correlated with their prognosis. Additionally, we analyzed the association of FAT1 with tumors from multiple perspectives, including single-cell sequencing, mutations, high tumor mutational burden, microsatellite instability, immune cell infiltration, and immune microenvironment. Our first pan-cancer study provided a relatively comprehensive understanding of the oncogenic role of FAT1 in tumors.