Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis

Ferroptosis is a recently-defined tumor suppression mechanism, but the sensitivity of many tumorigenic cells to ferroptosis is limited by their deficient expression of acyl-CoA synthetase long-chain family member 4 (ACSL4). Here, we report the discovery of a photosensitizer, namely TPCI, which can e...

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Detalles Bibliográficos
Autores principales: Wang, Xiuxia, Chen, Yuanhong, Yang, Xiang, Cheng, Lianghui, He, Zhenyan, Xin, Yanru, Huang, Shan, Meng, Fanling, Zhang, Peijing, Luo, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751149/
https://www.ncbi.nlm.nih.gov/pubmed/36517470
http://dx.doi.org/10.1038/s41419-022-05462-9

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