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The management of Helicobacter pylori infection and prevention and control of gastric cancer in China

Helicobacter pylori (H. pylori) infection, a type-1 carcinogen, was closely associated with gastric cancer (GC). Successfully eradicating H. pylori infection could reduce the incidence of GC. China was a country with high incidence of GC and high prevalence of H. pylori infection. Nearly half of wor...

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Autores principales: Hu, Yi, Zhu, Yin, Lu, Nong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751207/
https://www.ncbi.nlm.nih.gov/pubmed/36530421
http://dx.doi.org/10.3389/fcimb.2022.1049279
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author Hu, Yi
Zhu, Yin
Lu, Nong-Hua
author_facet Hu, Yi
Zhu, Yin
Lu, Nong-Hua
author_sort Hu, Yi
collection PubMed
description Helicobacter pylori (H. pylori) infection, a type-1 carcinogen, was closely associated with gastric cancer (GC). Successfully eradicating H. pylori infection could reduce the incidence of GC. China was a country with high incidence of GC and high prevalence of H. pylori infection. Nearly half of worldwide GC new cases and deaths attributed to H. pylori infection occurred in China. H. pylori prevalence varied over time with the improvement of socioeconomic status and sanitary conditions. The knowledge of antibiotic resistance rate in time was important to guide the clinical choice of antibiotics use in the regimens. With the publication of five Chinese consensus reports on the management of H. pylori infection and the effort of public preach of H. pylori-related knowledge, the standardization of H. pylori diagnosis and treatment by clinicians was improved. Bismuth-containing quadruple therapy was widely applied in clinical practice of H. pylori eradication because of high efficacy and safety. High-dose Proton Pump Inhibitor-amoxicillin dual therapy or vonoprazan-amoxicillin dual therapy showed comparable efficacy and lower side effects than bismuth-containing quadruple therapy, which were the alternative choice. The diagnosis rate of early GC was low and distinguishing Chinese GC risk population for the further endoscopy screening was important. Efforts have been done to establish prediction models to stratify GC risk in the Chinese GC risk population. We reviewed the current situation of the management of H. pylori infection and prevention and control of GC in China here.
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spelling pubmed-97512072022-12-16 The management of Helicobacter pylori infection and prevention and control of gastric cancer in China Hu, Yi Zhu, Yin Lu, Nong-Hua Front Cell Infect Microbiol Cellular and Infection Microbiology Helicobacter pylori (H. pylori) infection, a type-1 carcinogen, was closely associated with gastric cancer (GC). Successfully eradicating H. pylori infection could reduce the incidence of GC. China was a country with high incidence of GC and high prevalence of H. pylori infection. Nearly half of worldwide GC new cases and deaths attributed to H. pylori infection occurred in China. H. pylori prevalence varied over time with the improvement of socioeconomic status and sanitary conditions. The knowledge of antibiotic resistance rate in time was important to guide the clinical choice of antibiotics use in the regimens. With the publication of five Chinese consensus reports on the management of H. pylori infection and the effort of public preach of H. pylori-related knowledge, the standardization of H. pylori diagnosis and treatment by clinicians was improved. Bismuth-containing quadruple therapy was widely applied in clinical practice of H. pylori eradication because of high efficacy and safety. High-dose Proton Pump Inhibitor-amoxicillin dual therapy or vonoprazan-amoxicillin dual therapy showed comparable efficacy and lower side effects than bismuth-containing quadruple therapy, which were the alternative choice. The diagnosis rate of early GC was low and distinguishing Chinese GC risk population for the further endoscopy screening was important. Efforts have been done to establish prediction models to stratify GC risk in the Chinese GC risk population. We reviewed the current situation of the management of H. pylori infection and prevention and control of GC in China here. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751207/ /pubmed/36530421 http://dx.doi.org/10.3389/fcimb.2022.1049279 Text en Copyright © 2022 Hu, Zhu and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Hu, Yi
Zhu, Yin
Lu, Nong-Hua
The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title_full The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title_fullStr The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title_full_unstemmed The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title_short The management of Helicobacter pylori infection and prevention and control of gastric cancer in China
title_sort management of helicobacter pylori infection and prevention and control of gastric cancer in china
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751207/
https://www.ncbi.nlm.nih.gov/pubmed/36530421
http://dx.doi.org/10.3389/fcimb.2022.1049279
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