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Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea

Posttransplantation diabetes mellitus (PTDM) is an important metabolic complication after KT that causes graft failure and cardiovascular complications in kidney transplantation (KT) recipients. Using the national claim data of South Korea, 7612 KT recipients between 2009 and 2017 were analyzed. PTD...

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Autores principales: Kang, Eunjeong, Lee, Jangwook, Kang, Dong Hyun, Park, Jina, Park, Sehoon, Kim, Yong Chul, Kim, Dong Ki, Joo, Kwon Wook, Kim, Yon Su, Park, Minsu, Lim, Yaeji, Lee, Hajeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751267/
https://www.ncbi.nlm.nih.gov/pubmed/36517524
http://dx.doi.org/10.1038/s41598-022-25070-z
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author Kang, Eunjeong
Lee, Jangwook
Kang, Dong Hyun
Park, Jina
Park, Sehoon
Kim, Yong Chul
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Park, Minsu
Lim, Yaeji
Lee, Hajeong
author_facet Kang, Eunjeong
Lee, Jangwook
Kang, Dong Hyun
Park, Jina
Park, Sehoon
Kim, Yong Chul
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Park, Minsu
Lim, Yaeji
Lee, Hajeong
author_sort Kang, Eunjeong
collection PubMed
description Posttransplantation diabetes mellitus (PTDM) is an important metabolic complication after KT that causes graft failure and cardiovascular complications in kidney transplantation (KT) recipients. Using the national claim data of South Korea, 7612 KT recipients between 2009 and 2017 were analyzed. PTDM was defined as a consecutive 30-day prescription history of antidiabetic medication after KT. Among these patients, 24.7% were diagnosed with PTDM, and 51.9% were diagnosed within 6 months after KT. Compared to patients without PTDM, those with PTDM were older, more likely to be men, more likely to be diagnosed with hypertension and cardio-cerebrovascular disease, and experienced more rejection episodes requiring high-dose steroid treatment after KT. During the follow-up, 607 DCGFs, 230 DWGFs, 244 MACEs, and 260 all-cause mortality events occurred. Patients with PTDM showed a higher risk of DCGF (adjusted hazard ratio [aHR] 1.49; 95% confidence interval [CI] 1.22–1.82; P < 0.001) and MACEs (aHR 1.76; 95% CI 1.33–2.31; P < 0.001) than patients without PTDM. The risks for all clinical outcomes were higher in the insulin group than in the non-use insulin group. PTDM in KT recipients resulted in both worse allograft and patient outcomes represented by DCGF and MACE, especially in patients needing insulin treatment.
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spelling pubmed-97512672022-12-16 Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea Kang, Eunjeong Lee, Jangwook Kang, Dong Hyun Park, Jina Park, Sehoon Kim, Yong Chul Kim, Dong Ki Joo, Kwon Wook Kim, Yon Su Park, Minsu Lim, Yaeji Lee, Hajeong Sci Rep Article Posttransplantation diabetes mellitus (PTDM) is an important metabolic complication after KT that causes graft failure and cardiovascular complications in kidney transplantation (KT) recipients. Using the national claim data of South Korea, 7612 KT recipients between 2009 and 2017 were analyzed. PTDM was defined as a consecutive 30-day prescription history of antidiabetic medication after KT. Among these patients, 24.7% were diagnosed with PTDM, and 51.9% were diagnosed within 6 months after KT. Compared to patients without PTDM, those with PTDM were older, more likely to be men, more likely to be diagnosed with hypertension and cardio-cerebrovascular disease, and experienced more rejection episodes requiring high-dose steroid treatment after KT. During the follow-up, 607 DCGFs, 230 DWGFs, 244 MACEs, and 260 all-cause mortality events occurred. Patients with PTDM showed a higher risk of DCGF (adjusted hazard ratio [aHR] 1.49; 95% confidence interval [CI] 1.22–1.82; P < 0.001) and MACEs (aHR 1.76; 95% CI 1.33–2.31; P < 0.001) than patients without PTDM. The risks for all clinical outcomes were higher in the insulin group than in the non-use insulin group. PTDM in KT recipients resulted in both worse allograft and patient outcomes represented by DCGF and MACE, especially in patients needing insulin treatment. Nature Publishing Group UK 2022-12-14 /pmc/articles/PMC9751267/ /pubmed/36517524 http://dx.doi.org/10.1038/s41598-022-25070-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kang, Eunjeong
Lee, Jangwook
Kang, Dong Hyun
Park, Jina
Park, Sehoon
Kim, Yong Chul
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Park, Minsu
Lim, Yaeji
Lee, Hajeong
Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_full Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_fullStr Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_full_unstemmed Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_short Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
title_sort clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751267/
https://www.ncbi.nlm.nih.gov/pubmed/36517524
http://dx.doi.org/10.1038/s41598-022-25070-z
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