Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens

The development of cancer therapies is limited by the availability of suitable drug targets. Potential candidate drug targets can be identified based on the concept of synthetic lethality (SL), which refers to pairs of genes for which an aberration in either gene alone is non-lethal, but co-occurren...

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Detalles Bibliográficos
Autores principales: Srivatsa, Sumana, Montazeri, Hesam, Bianco, Gaia, Coto-Llerena, Mairene, Marinucci, Mattia, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Beerenwinkel, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751287/
https://www.ncbi.nlm.nih.gov/pubmed/36517508
http://dx.doi.org/10.1038/s41467-022-35378-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751287/
https://www.ncbi.nlm.nih.gov/pubmed/36517508
http://dx.doi.org/10.1038/s41467-022-35378-z

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