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Discovery of synthetic lethal interactions from large-scale pan-cancer perturbation screens
The development of cancer therapies is limited by the availability of suitable drug targets. Potential candidate drug targets can be identified based on the concept of synthetic lethality (SL), which refers to pairs of genes for which an aberration in either gene alone is non-lethal, but co-occurren...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751287/ https://www.ncbi.nlm.nih.gov/pubmed/36517508 http://dx.doi.org/10.1038/s41467-022-35378-z |