The botanical drug PBI-05204, a supercritical CO(2) extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of resistance to therapies, despite improvements...

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Detalles Bibliográficos
Autores principales: Vaccaro, Sara, Rossetti, Alessandra, Porrazzo, Antonella, Camero, Simona, Cassandri, Matteo, Pomella, Silvia, Tomaciello, Miriam, Macioce, Giampiero, Pedini, Francesca, Barillari, Giovanni, Marchese, Cinzia, Rota, Rossella, Cenci, Giovanni, Tombolini, Mario, Newman, Robert A., Yang, Peiying, Codenotti, Silvia, Fanzani, Alessandro, Megiorni, Francesca, Festuccia, Claudio, Minniti, Giuseppe, Gravina, Giovanni Luca, Vulcano, Francesca, Milazzo, Luisa, Marampon, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751381/
https://www.ncbi.nlm.nih.gov/pubmed/36532747
http://dx.doi.org/10.3389/fphar.2022.1071176

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