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Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines

INTRODUCTION: Methotrexate (MTX), a folic acid antagonist and nucleotide synthesis inhibitor, is a cornerstone drug used against acute lymphoblastic leukemia (ALL), but its mechanism of action and resistance continues to be unraveled even after decades of clinical use. METHODS: To better understand...

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Autores principales:	Canevarolo, Rafael Renatino, Melo, Carolina Pereira de Souza, Cury, Nathalia Moreno, Artico, Leonardo Luiz, Corrêa, Juliana Ronchi, Lau, Yanca Tonhasca, Mariano, Samara Sousa, Sudalagunta, Praneeth Reddy, Brandalise, Silvia Regina, Zeri, Ana Carolina de Mattos, Yunes, José Andrés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751399/ https://www.ncbi.nlm.nih.gov/pubmed/36531023 http://dx.doi.org/10.3389/fonc.2022.1032336

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