Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic

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Type-III CRISPR-Cas systems have recently been adopted for sequence-specific detection of SARS-CoV-2. Here, we repurpose the type III-A CRISPR complex from Thermus thermophilus (TtCsm) for programmable capture and concentration of specific RNAs from complex mixtures. The target bound TtCsm complex g...

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Detalles Bibliográficos
Autores principales: Nemudraia, Anna, Nemudryi, Artem, Buyukyoruk, Murat, Scherffius, Andrew M., Zahl, Trevor, Wiegand, Tanner, Pandey, Shishir, Nichols, Joseph E., Hall, Laina N., McVey, Aidan, Lee, Helen H., Wilkinson, Royce A., Snyder, Laura R., Jones, Joshua D., Koutmou, Kristin S., Santiago-Frangos, Andrew, Wiedenheft, Blake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751510/
https://www.ncbi.nlm.nih.gov/pubmed/36522348
http://dx.doi.org/10.1038/s41467-022-35445-5
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