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The potential therapeutic value and application prospect of engineered exosomes in human diseases

Exosomes are tiny vesicles produced by a wide range of cells that contain complex RNA and protein. In the diagnosis, treatment, and prevention of illness, they offer great potential. In vitro engineering technique modifies exosomes to produce designed exosomes that include nucleic acids, proteins, a...

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Detalles Bibliográficos
Autores principales: Liu, Gege, Wu, Junlu, Chen, Guofei, Shang, Anquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751586/
https://www.ncbi.nlm.nih.gov/pubmed/36531952
http://dx.doi.org/10.3389/fcell.2022.1051380
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author Liu, Gege
Wu, Junlu
Chen, Guofei
Shang, Anquan
author_facet Liu, Gege
Wu, Junlu
Chen, Guofei
Shang, Anquan
author_sort Liu, Gege
collection PubMed
description Exosomes are tiny vesicles produced by a wide range of cells that contain complex RNA and protein. In the diagnosis, treatment, and prevention of illness, they offer great potential. In vitro engineering technique modifies exosomes to produce designed exosomes that include nucleic acids, proteins, and medicines, and are targeted to particular tissues or cells. Their applications range from tumor imaging and gene therapy to vaccine production and regenerative medicine to targeted medication delivery. Many disciplines have promising futures for using this technology. In this review, we’ll look at the potential therapeutic usefulness and use of engineered exosomes in a variety of human illnesses with various systemic manifestations.
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spelling pubmed-97515862022-12-16 The potential therapeutic value and application prospect of engineered exosomes in human diseases Liu, Gege Wu, Junlu Chen, Guofei Shang, Anquan Front Cell Dev Biol Cell and Developmental Biology Exosomes are tiny vesicles produced by a wide range of cells that contain complex RNA and protein. In the diagnosis, treatment, and prevention of illness, they offer great potential. In vitro engineering technique modifies exosomes to produce designed exosomes that include nucleic acids, proteins, and medicines, and are targeted to particular tissues or cells. Their applications range from tumor imaging and gene therapy to vaccine production and regenerative medicine to targeted medication delivery. Many disciplines have promising futures for using this technology. In this review, we’ll look at the potential therapeutic usefulness and use of engineered exosomes in a variety of human illnesses with various systemic manifestations. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751586/ /pubmed/36531952 http://dx.doi.org/10.3389/fcell.2022.1051380 Text en Copyright © 2022 Liu, Wu, Chen and Shang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Gege
Wu, Junlu
Chen, Guofei
Shang, Anquan
The potential therapeutic value and application prospect of engineered exosomes in human diseases
title The potential therapeutic value and application prospect of engineered exosomes in human diseases
title_full The potential therapeutic value and application prospect of engineered exosomes in human diseases
title_fullStr The potential therapeutic value and application prospect of engineered exosomes in human diseases
title_full_unstemmed The potential therapeutic value and application prospect of engineered exosomes in human diseases
title_short The potential therapeutic value and application prospect of engineered exosomes in human diseases
title_sort potential therapeutic value and application prospect of engineered exosomes in human diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751586/
https://www.ncbi.nlm.nih.gov/pubmed/36531952
http://dx.doi.org/10.3389/fcell.2022.1051380
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