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Peripheral vascular remodeling during ischemia
About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia, diabetes, and hypertension, can contribute to the development of PAD. PAD is typically characterized by intermitten...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751613/ https://www.ncbi.nlm.nih.gov/pubmed/36532724 http://dx.doi.org/10.3389/fphar.2022.1078047 |
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author | Lin, Shigang Lin, Ruoran Zhang, Hongkun Xu, Qingbo He, Yangyan |
author_facet | Lin, Shigang Lin, Ruoran Zhang, Hongkun Xu, Qingbo He, Yangyan |
author_sort | Lin, Shigang |
collection | PubMed |
description | About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia, diabetes, and hypertension, can contribute to the development of PAD. PAD is typically characterized by intermittent claudication and resting pain, and there is a risk of severe limb ischemia, leading to major adverse limb events, such as amputation. Currently, a major progress in the research field of the pathogenesis of vascular remodeling, including atherosclerosis and neointima hyperplasia has been made. For example, the molecular mechanisms of endothelial dysfunction and smooth muscle phenotype switching have been described. Interestingly, a series of focused studies on fibroblasts of the vessel wall has demonstrated their impact on smooth muscle proliferation and even endothelial function via cell-cell communications. In this review, we aim to focus on the functional changes of peripheral arterial cells and the mechanisms of the pathogenesis of PAD. At the same time, we summarize the progress of the current clinical treatment and potential therapeutic methods for PAD and shine a light on future perspectives. |
format | Online Article Text |
id | pubmed-9751613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97516132022-12-16 Peripheral vascular remodeling during ischemia Lin, Shigang Lin, Ruoran Zhang, Hongkun Xu, Qingbo He, Yangyan Front Pharmacol Pharmacology About 230 million people worldwide suffer from peripheral arterial disease (PAD), and the prevalence is increasing year by year. Multiple risk factors, including smoking, dyslipidemia, diabetes, and hypertension, can contribute to the development of PAD. PAD is typically characterized by intermittent claudication and resting pain, and there is a risk of severe limb ischemia, leading to major adverse limb events, such as amputation. Currently, a major progress in the research field of the pathogenesis of vascular remodeling, including atherosclerosis and neointima hyperplasia has been made. For example, the molecular mechanisms of endothelial dysfunction and smooth muscle phenotype switching have been described. Interestingly, a series of focused studies on fibroblasts of the vessel wall has demonstrated their impact on smooth muscle proliferation and even endothelial function via cell-cell communications. In this review, we aim to focus on the functional changes of peripheral arterial cells and the mechanisms of the pathogenesis of PAD. At the same time, we summarize the progress of the current clinical treatment and potential therapeutic methods for PAD and shine a light on future perspectives. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751613/ /pubmed/36532724 http://dx.doi.org/10.3389/fphar.2022.1078047 Text en Copyright © 2022 Lin, Lin, Zhang, Xu and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Lin, Shigang Lin, Ruoran Zhang, Hongkun Xu, Qingbo He, Yangyan Peripheral vascular remodeling during ischemia |
title | Peripheral vascular remodeling during ischemia |
title_full | Peripheral vascular remodeling during ischemia |
title_fullStr | Peripheral vascular remodeling during ischemia |
title_full_unstemmed | Peripheral vascular remodeling during ischemia |
title_short | Peripheral vascular remodeling during ischemia |
title_sort | peripheral vascular remodeling during ischemia |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751613/ https://www.ncbi.nlm.nih.gov/pubmed/36532724 http://dx.doi.org/10.3389/fphar.2022.1078047 |
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