Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case

An 82-year-old man with fever and back pain was referred to our hospital and was thus found to be thrombocytopenic. A bone marrow biopsy revealed the diffuse infiltration of poorly differentiated neuroendocrine carcinoma (NEC). Computed tomography revealed a large hepatic mass. Considering the risk...

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Autores principales: Nakano, Shogo, Minaga, Kosuke, Tani, Yasuhiro, Tonomura, Kohei, Hanawa, Yusuke, Morimura, Hiroki, Terashita, Tomoko, Matsumoto, Hisakazu, Iwagami, Hiroyoshi, Nakatani, Yasuki, Akamatsu, Takuji, Uenoyama, Yoshito, Maeda, Chikara, Ono, Kazuo, Watanabe, Tomohiro, Yamashita, Yukitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751712/
https://www.ncbi.nlm.nih.gov/pubmed/35400708
http://dx.doi.org/10.2169/internalmedicine.9465-22
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author Nakano, Shogo
Minaga, Kosuke
Tani, Yasuhiro
Tonomura, Kohei
Hanawa, Yusuke
Morimura, Hiroki
Terashita, Tomoko
Matsumoto, Hisakazu
Iwagami, Hiroyoshi
Nakatani, Yasuki
Akamatsu, Takuji
Uenoyama, Yoshito
Maeda, Chikara
Ono, Kazuo
Watanabe, Tomohiro
Yamashita, Yukitaka
author_facet Nakano, Shogo
Minaga, Kosuke
Tani, Yasuhiro
Tonomura, Kohei
Hanawa, Yusuke
Morimura, Hiroki
Terashita, Tomoko
Matsumoto, Hisakazu
Iwagami, Hiroyoshi
Nakatani, Yasuki
Akamatsu, Takuji
Uenoyama, Yoshito
Maeda, Chikara
Ono, Kazuo
Watanabe, Tomohiro
Yamashita, Yukitaka
author_sort Nakano, Shogo
collection PubMed
description An 82-year-old man with fever and back pain was referred to our hospital and was thus found to be thrombocytopenic. A bone marrow biopsy revealed the diffuse infiltration of poorly differentiated neuroendocrine carcinoma (NEC). Computed tomography revealed a large hepatic mass. Considering the risk of bleeding due to thrombocytopenia, a needle biopsy was not performed. The patient rapidly deteriorated and died 10 days after presentation. An autopsy confirmed the diagnosis of primary hepatic NEC, with diffuse metastasis to the spleen, bone marrow, and systemic lymph nodes. This is an extremely rare case of NEC presenting with thrombocytopenia due to extensive bone marrow and splenic infiltration.
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spelling pubmed-97517122022-12-22 Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case Nakano, Shogo Minaga, Kosuke Tani, Yasuhiro Tonomura, Kohei Hanawa, Yusuke Morimura, Hiroki Terashita, Tomoko Matsumoto, Hisakazu Iwagami, Hiroyoshi Nakatani, Yasuki Akamatsu, Takuji Uenoyama, Yoshito Maeda, Chikara Ono, Kazuo Watanabe, Tomohiro Yamashita, Yukitaka Intern Med Case Report An 82-year-old man with fever and back pain was referred to our hospital and was thus found to be thrombocytopenic. A bone marrow biopsy revealed the diffuse infiltration of poorly differentiated neuroendocrine carcinoma (NEC). Computed tomography revealed a large hepatic mass. Considering the risk of bleeding due to thrombocytopenia, a needle biopsy was not performed. The patient rapidly deteriorated and died 10 days after presentation. An autopsy confirmed the diagnosis of primary hepatic NEC, with diffuse metastasis to the spleen, bone marrow, and systemic lymph nodes. This is an extremely rare case of NEC presenting with thrombocytopenia due to extensive bone marrow and splenic infiltration. The Japanese Society of Internal Medicine 2022-04-09 2022-11-15 /pmc/articles/PMC9751712/ /pubmed/35400708 http://dx.doi.org/10.2169/internalmedicine.9465-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakano, Shogo
Minaga, Kosuke
Tani, Yasuhiro
Tonomura, Kohei
Hanawa, Yusuke
Morimura, Hiroki
Terashita, Tomoko
Matsumoto, Hisakazu
Iwagami, Hiroyoshi
Nakatani, Yasuki
Akamatsu, Takuji
Uenoyama, Yoshito
Maeda, Chikara
Ono, Kazuo
Watanabe, Tomohiro
Yamashita, Yukitaka
Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title_full Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title_fullStr Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title_full_unstemmed Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title_short Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case
title_sort primary hepatic neuroendocrine carcinoma with thrombocytopenia due to diffuse bone marrow and splenic infiltration: an autopsy case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751712/
https://www.ncbi.nlm.nih.gov/pubmed/35400708
http://dx.doi.org/10.2169/internalmedicine.9465-22
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