A Patient with Acute Kidney Injury Associated with Massive Proteinuria and Acute Hyperuricemia after Epileptic Seizures

A 25-year-old man presented with acute kidney injury (AKI), massive proteinuria and hyperuricemia after epileptic seizures. His AKI improved along with the disappearance of proteinuria after corticosteroid treatment. A kidney biopsy revealed no significant glomerular abnormalities, but varying degre...

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Detalles Bibliográficos
Autores principales: Tomomitsu, Yoshihiro, Asakawa, Shinichiro, Arai, Shigeyuki, Nagura, Michito, Ishizawa, Kenichi, Yamazaki, Osamu, Tamura, Yoshifuru, Uchida, Shunya, Ohashi, Ryuji, Shibata, Shigeru, Fujigaki, Yoshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751716/
https://www.ncbi.nlm.nih.gov/pubmed/35466163
http://dx.doi.org/10.2169/internalmedicine.8808-21
Descripción
Sumario:A 25-year-old man presented with acute kidney injury (AKI), massive proteinuria and hyperuricemia after epileptic seizures. His AKI improved along with the disappearance of proteinuria after corticosteroid treatment. A kidney biopsy revealed no significant glomerular abnormalities, but varying degrees of tubular injury, such as proximal tubular simplification, mild distal tubular proliferation, and Tamm-Horsfall protein-like material accumulation with extravasation into the interstitium, were noted. A further analysis revealed the intratubular depositions of uric acid crystals, indicating the involvement of acute uric acid nephropathy associated with seizures. Our patient's condition is rare, and the clinicopathological aspects of the diagnostic challenges are discussed.

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