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An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection

We herein report a case of cerebral infarct in a patient with coronavirus disease 2019 (COVID-19) infection who died of aspiration pneumonia. The postmortem examination of the brain revealed embolic infarct with negative findings on quantitative reverse transcription polymerase chain reaction (qRT-P...

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Autores principales: Goto, Ryoji, Kawakami, Haruka, Horiuchi, Yurino, Chikada, Ayaka, Yasuda, Tsutomu, Suzuki, Tetsuya, Miyazato, Yusuke, Ishikane, Masahiro, Kishino, Yuya, Miyazaki, Hideki, Igari, Toru, Katano, Harutaka, Suzuki, Tadaki, Murayama, Shigeo, Arai, Noritoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751720/
https://www.ncbi.nlm.nih.gov/pubmed/36070957
http://dx.doi.org/10.2169/internalmedicine.9726-22
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author Goto, Ryoji
Kawakami, Haruka
Horiuchi, Yurino
Chikada, Ayaka
Yasuda, Tsutomu
Suzuki, Tetsuya
Miyazato, Yusuke
Ishikane, Masahiro
Kishino, Yuya
Miyazaki, Hideki
Igari, Toru
Katano, Harutaka
Suzuki, Tadaki
Murayama, Shigeo
Arai, Noritoshi
author_facet Goto, Ryoji
Kawakami, Haruka
Horiuchi, Yurino
Chikada, Ayaka
Yasuda, Tsutomu
Suzuki, Tetsuya
Miyazato, Yusuke
Ishikane, Masahiro
Kishino, Yuya
Miyazaki, Hideki
Igari, Toru
Katano, Harutaka
Suzuki, Tadaki
Murayama, Shigeo
Arai, Noritoshi
author_sort Goto, Ryoji
collection PubMed
description We herein report a case of cerebral infarct in a patient with coronavirus disease 2019 (COVID-19) infection who died of aspiration pneumonia. The postmortem examination of the brain revealed embolic infarct with negative findings on quantitative reverse transcription polymerase chain reaction (qRT-PCR) as well as immunohistochemistry to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The systemic examination only revealed low copy numbers of SARS-CoV-2 in the bronchus. This is the first and so far only autopsy case of COVID-19 infection with pathologic and virologic findings of the postmortem brain in Japan.
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spelling pubmed-97517202022-12-22 An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection Goto, Ryoji Kawakami, Haruka Horiuchi, Yurino Chikada, Ayaka Yasuda, Tsutomu Suzuki, Tetsuya Miyazato, Yusuke Ishikane, Masahiro Kishino, Yuya Miyazaki, Hideki Igari, Toru Katano, Harutaka Suzuki, Tadaki Murayama, Shigeo Arai, Noritoshi Intern Med Case Report We herein report a case of cerebral infarct in a patient with coronavirus disease 2019 (COVID-19) infection who died of aspiration pneumonia. The postmortem examination of the brain revealed embolic infarct with negative findings on quantitative reverse transcription polymerase chain reaction (qRT-PCR) as well as immunohistochemistry to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The systemic examination only revealed low copy numbers of SARS-CoV-2 in the bronchus. This is the first and so far only autopsy case of COVID-19 infection with pathologic and virologic findings of the postmortem brain in Japan. The Japanese Society of Internal Medicine 2022-09-06 2022-11-15 /pmc/articles/PMC9751720/ /pubmed/36070957 http://dx.doi.org/10.2169/internalmedicine.9726-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Goto, Ryoji
Kawakami, Haruka
Horiuchi, Yurino
Chikada, Ayaka
Yasuda, Tsutomu
Suzuki, Tetsuya
Miyazato, Yusuke
Ishikane, Masahiro
Kishino, Yuya
Miyazaki, Hideki
Igari, Toru
Katano, Harutaka
Suzuki, Tadaki
Murayama, Shigeo
Arai, Noritoshi
An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title_full An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title_fullStr An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title_full_unstemmed An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title_short An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection
title_sort autopsy report of a case with cerebral infarction complicated by coronavirus disease 2019 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751720/
https://www.ncbi.nlm.nih.gov/pubmed/36070957
http://dx.doi.org/10.2169/internalmedicine.9726-22
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