Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS

Persistent viral shedding or prolonged coronavirus disease 2019 (COVID-19) symptom is one of unresolved problem in immunocompromised individuals. We herein report an HIV/AIDS patient with Pneumocystis jirovecii pneumonia and prolonged COVID-19, possibly due to immune reconstitution inflammatory synd...

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Autores principales: Adachi, Eisuke, Saito, Makoto, Koga, Michiko, Tsutsumi, Takeya, Yotsuyanagi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751733/
https://www.ncbi.nlm.nih.gov/pubmed/36070950
http://dx.doi.org/10.2169/internalmedicine.0485-22
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author Adachi, Eisuke
Saito, Makoto
Koga, Michiko
Tsutsumi, Takeya
Yotsuyanagi, Hiroshi
author_facet Adachi, Eisuke
Saito, Makoto
Koga, Michiko
Tsutsumi, Takeya
Yotsuyanagi, Hiroshi
author_sort Adachi, Eisuke
collection PubMed
description Persistent viral shedding or prolonged coronavirus disease 2019 (COVID-19) symptom is one of unresolved problem in immunocompromised individuals. We herein report an HIV/AIDS patient with Pneumocystis jirovecii pneumonia and prolonged COVID-19, possibly due to immune reconstitution inflammatory syndrome. His viral shedding and COVID-19 symptoms persisted for 39 days but were promptly resolved following sotrovimab monoclonal antibody therapy. This case suggests that prolonged COVID-19 and persistent viral shedding due to severe cellular immunodeficiency can occur in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron infection and that sotrovimab is effective in the treatment of prolonged COVID-19 caused by omicron/BA.1.
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spelling pubmed-97517332022-12-22 Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS Adachi, Eisuke Saito, Makoto Koga, Michiko Tsutsumi, Takeya Yotsuyanagi, Hiroshi Intern Med Case Report Persistent viral shedding or prolonged coronavirus disease 2019 (COVID-19) symptom is one of unresolved problem in immunocompromised individuals. We herein report an HIV/AIDS patient with Pneumocystis jirovecii pneumonia and prolonged COVID-19, possibly due to immune reconstitution inflammatory syndrome. His viral shedding and COVID-19 symptoms persisted for 39 days but were promptly resolved following sotrovimab monoclonal antibody therapy. This case suggests that prolonged COVID-19 and persistent viral shedding due to severe cellular immunodeficiency can occur in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron infection and that sotrovimab is effective in the treatment of prolonged COVID-19 caused by omicron/BA.1. The Japanese Society of Internal Medicine 2022-09-06 2022-11-15 /pmc/articles/PMC9751733/ /pubmed/36070950 http://dx.doi.org/10.2169/internalmedicine.0485-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adachi, Eisuke
Saito, Makoto
Koga, Michiko
Tsutsumi, Takeya
Yotsuyanagi, Hiroshi
Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title_full Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title_fullStr Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title_full_unstemmed Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title_short Favorable Outcome Following Sotrovimab Monoclonal Antibody in a Patient with Prolonged SARS-CoV-2 Omicron Infection with HIV/AIDS
title_sort favorable outcome following sotrovimab monoclonal antibody in a patient with prolonged sars-cov-2 omicron infection with hiv/aids
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751733/
https://www.ncbi.nlm.nih.gov/pubmed/36070950
http://dx.doi.org/10.2169/internalmedicine.0485-22
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