Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma

Parathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with met...

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Autores principales: Makino, Hirofumi, Notsu, Masakazu, Asayama, Itsuko, Otani, Hazuki, Morita, Miwa, Yamamoto, Masahiro, Yamauchi, Mika, Nakao, Mika, Miyake, Hitomi, Araki, Asuka, Uchino, Shinya, Kanasaki, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751735/
https://www.ncbi.nlm.nih.gov/pubmed/35370235
http://dx.doi.org/10.2169/internalmedicine.9261-21
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author Makino, Hirofumi
Notsu, Masakazu
Asayama, Itsuko
Otani, Hazuki
Morita, Miwa
Yamamoto, Masahiro
Yamauchi, Mika
Nakao, Mika
Miyake, Hitomi
Araki, Asuka
Uchino, Shinya
Kanasaki, Keizo
author_facet Makino, Hirofumi
Notsu, Masakazu
Asayama, Itsuko
Otani, Hazuki
Morita, Miwa
Yamamoto, Masahiro
Yamauchi, Mika
Nakao, Mika
Miyake, Hitomi
Araki, Asuka
Uchino, Shinya
Kanasaki, Keizo
author_sort Makino, Hirofumi
collection PubMed
description Parathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with metastatic PC who was treated with sorafenib, a multikinase inhibitor. In this case, the serum calcium level was under control for 10 months after the initiation of sorafenib. This case suggests that combination therapy with sorafenib, evocalcet, and denosumab may be an alternative, stronger management option for refractory hypercalcemia in recurrent PC.
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spelling pubmed-97517352022-12-22 Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma Makino, Hirofumi Notsu, Masakazu Asayama, Itsuko Otani, Hazuki Morita, Miwa Yamamoto, Masahiro Yamauchi, Mika Nakao, Mika Miyake, Hitomi Araki, Asuka Uchino, Shinya Kanasaki, Keizo Intern Med Case Report Parathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with metastatic PC who was treated with sorafenib, a multikinase inhibitor. In this case, the serum calcium level was under control for 10 months after the initiation of sorafenib. This case suggests that combination therapy with sorafenib, evocalcet, and denosumab may be an alternative, stronger management option for refractory hypercalcemia in recurrent PC. The Japanese Society of Internal Medicine 2022-04-02 2022-11-15 /pmc/articles/PMC9751735/ /pubmed/35370235 http://dx.doi.org/10.2169/internalmedicine.9261-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Makino, Hirofumi
Notsu, Masakazu
Asayama, Itsuko
Otani, Hazuki
Morita, Miwa
Yamamoto, Masahiro
Yamauchi, Mika
Nakao, Mika
Miyake, Hitomi
Araki, Asuka
Uchino, Shinya
Kanasaki, Keizo
Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title_full Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title_fullStr Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title_full_unstemmed Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title_short Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
title_sort successful control of hypercalcemia with sorafenib, evocalcet, and denosumab combination therapy for recurrent parathyroid carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751735/
https://www.ncbi.nlm.nih.gov/pubmed/35370235
http://dx.doi.org/10.2169/internalmedicine.9261-21
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