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Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment

The comprehensive profiling of glycoproteins is of great significance for the timely clinical diagnosis and therapy. However, inherent obstacles hamper their direct analysis from biological samples, and specific enrichment prior to analysis is indispensable. Among the various approaches for glycopep...

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Autores principales: Li, Siqi, Wei, Yuanhua, Wang, Ya, Liang, Haoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751774/
https://www.ncbi.nlm.nih.gov/pubmed/36531319
http://dx.doi.org/10.3389/fchem.2022.1091243
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author Li, Siqi
Wei, Yuanhua
Wang, Ya
Liang, Haoran
author_facet Li, Siqi
Wei, Yuanhua
Wang, Ya
Liang, Haoran
author_sort Li, Siqi
collection PubMed
description The comprehensive profiling of glycoproteins is of great significance for the timely clinical diagnosis and therapy. However, inherent obstacles hamper their direct analysis from biological samples, and specific enrichment prior to analysis is indispensable. Among the various approaches for glycopeptide enrichment, hydrophilic interaction liquid chromatography (HILIC) has attracted special focus, especially for the development of novel hydrophilic materials, which is the key of HILIC. Metal–organic frameworks (MOFs) are a type of porous materials constructed from the self-assembly of metal and organic linkers. Advantages such as high surface area, flexible pore size, and easy modification render hydrophilic MOFs as ideal candidates for HILIC, which has inspired many studies over the past years. In this review, advances in hydrophilic MOFs for N-linked glycopeptide enrichment are summarized. According to the synthesis strategies, those materials are categorized into three classes, namely pristine MOFs, MOFs with chemical modifications, and MOFs-derived composite. In each categorization, the preparation and the function of different moieties are covered, as well as the enrichment performances of sensitivity, selectivity, and practical application. Finally, a summary and future perspective on the applications of hydrophilic MOFs for N-linked glycopeptide enrichment are briefly discussed. This review is expected to raise awareness of the properties of hydrophilic MOFs and offer some valuable information to further research in glycoproteomics.
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spelling pubmed-97517742022-12-16 Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment Li, Siqi Wei, Yuanhua Wang, Ya Liang, Haoran Front Chem Chemistry The comprehensive profiling of glycoproteins is of great significance for the timely clinical diagnosis and therapy. However, inherent obstacles hamper their direct analysis from biological samples, and specific enrichment prior to analysis is indispensable. Among the various approaches for glycopeptide enrichment, hydrophilic interaction liquid chromatography (HILIC) has attracted special focus, especially for the development of novel hydrophilic materials, which is the key of HILIC. Metal–organic frameworks (MOFs) are a type of porous materials constructed from the self-assembly of metal and organic linkers. Advantages such as high surface area, flexible pore size, and easy modification render hydrophilic MOFs as ideal candidates for HILIC, which has inspired many studies over the past years. In this review, advances in hydrophilic MOFs for N-linked glycopeptide enrichment are summarized. According to the synthesis strategies, those materials are categorized into three classes, namely pristine MOFs, MOFs with chemical modifications, and MOFs-derived composite. In each categorization, the preparation and the function of different moieties are covered, as well as the enrichment performances of sensitivity, selectivity, and practical application. Finally, a summary and future perspective on the applications of hydrophilic MOFs for N-linked glycopeptide enrichment are briefly discussed. This review is expected to raise awareness of the properties of hydrophilic MOFs and offer some valuable information to further research in glycoproteomics. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751774/ /pubmed/36531319 http://dx.doi.org/10.3389/fchem.2022.1091243 Text en Copyright © 2022 Li, Wei, Wang and Liang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Li, Siqi
Wei, Yuanhua
Wang, Ya
Liang, Haoran
Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title_full Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title_fullStr Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title_full_unstemmed Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title_short Advances in hydrophilic metal–organic frameworks for N-linked glycopeptide enrichment
title_sort advances in hydrophilic metal–organic frameworks for n-linked glycopeptide enrichment
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751774/
https://www.ncbi.nlm.nih.gov/pubmed/36531319
http://dx.doi.org/10.3389/fchem.2022.1091243
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