521. Investigating the Gram-Positive Selective Spectrum of Ibezapolstat, a First-in-Class DNA Polymerase IIIC (Pol IIIC) Inhibitor

BACKGROUND: Ibezapolstat (IBZ) is a non-absorbable antimicrobial currently in phase 2 clinical trials for the treatment of Clostridioides difficile infection (CDI). In vitro and human studies have shown potent activity of IBZ against C. difficile but selective activity against other beneficial Gram-...

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Detalles Bibliográficos
Autores principales: Jahangir Alam, M, Begum, Khurshida, Karim, Md Ekramul, Hu, Chenlin, Basseres, Eugenie, Lancaster, Chris, Garey, Kevin W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751893/
http://dx.doi.org/10.1093/ofid/ofac492.576

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