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Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series

Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune, astrocytopathic diseases affecting the central nervous system(CNS), especially the central optic nerve and spinal cord. Aquaporin 4-immunoglobulin G (AQP4-IgG) is the dominant pathogenic antibody and can be detected in about 80% of pati...

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Autores principales: Duan, Yinghui, Wang, Xin, Duan, Xiaoyu, Gao, Hanqing, Ji, Xiaopei, Xiao, Xinyi, Zhu, Feng, Xue, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751951/
https://www.ncbi.nlm.nih.gov/pubmed/36530632
http://dx.doi.org/10.3389/fneur.2022.1071519
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author Duan, Yinghui
Wang, Xin
Duan, Xiaoyu
Gao, Hanqing
Ji, Xiaopei
Xiao, Xinyi
Zhu, Feng
Xue, Qun
author_facet Duan, Yinghui
Wang, Xin
Duan, Xiaoyu
Gao, Hanqing
Ji, Xiaopei
Xiao, Xinyi
Zhu, Feng
Xue, Qun
author_sort Duan, Yinghui
collection PubMed
description Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune, astrocytopathic diseases affecting the central nervous system(CNS), especially the central optic nerve and spinal cord. Aquaporin 4-immunoglobulin G (AQP4-IgG) is the dominant pathogenic antibody and can be detected in about 80% of patients with NMOSD. Although only a few cases were reported on NMOSD associated with cancer, they demonstrated the potential paraneoplastic link between cancer and NMOSD. In the present study, we report three NMOSD cases associated with cancer, which are teratoma and lung adenocarcinoma, teratoma, and transverse colon adenocarcinoma, respectively. Pathological staining of tumor sections revealed a high AQP4 expression. After tumor removal, all cases were stable and suffered no further relapses, which revealed the potential paraneoplastic mechanism between cancer and NMOSD. One of our patient's serum AQP4-IgG was transiently slightly elevated even though AQP4 was highly expressed in tumor cells, which indicates that AQP4 is not the main pathogenic antibody but might be induced by other underlying pathogenic antibody–antigen reactions.
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spelling pubmed-97519512022-12-16 Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series Duan, Yinghui Wang, Xin Duan, Xiaoyu Gao, Hanqing Ji, Xiaopei Xiao, Xinyi Zhu, Feng Xue, Qun Front Neurol Neurology Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune, astrocytopathic diseases affecting the central nervous system(CNS), especially the central optic nerve and spinal cord. Aquaporin 4-immunoglobulin G (AQP4-IgG) is the dominant pathogenic antibody and can be detected in about 80% of patients with NMOSD. Although only a few cases were reported on NMOSD associated with cancer, they demonstrated the potential paraneoplastic link between cancer and NMOSD. In the present study, we report three NMOSD cases associated with cancer, which are teratoma and lung adenocarcinoma, teratoma, and transverse colon adenocarcinoma, respectively. Pathological staining of tumor sections revealed a high AQP4 expression. After tumor removal, all cases were stable and suffered no further relapses, which revealed the potential paraneoplastic mechanism between cancer and NMOSD. One of our patient's serum AQP4-IgG was transiently slightly elevated even though AQP4 was highly expressed in tumor cells, which indicates that AQP4 is not the main pathogenic antibody but might be induced by other underlying pathogenic antibody–antigen reactions. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9751951/ /pubmed/36530632 http://dx.doi.org/10.3389/fneur.2022.1071519 Text en Copyright © 2022 Duan, Wang, Duan, Gao, Ji, Xiao, Zhu and Xue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Duan, Yinghui
Wang, Xin
Duan, Xiaoyu
Gao, Hanqing
Ji, Xiaopei
Xiao, Xinyi
Zhu, Feng
Xue, Qun
Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title_full Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title_fullStr Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title_full_unstemmed Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title_short Neuromyelitis optica spectrum disorders associated with AQP4-positive-cancer—A case series
title_sort neuromyelitis optica spectrum disorders associated with aqp4-positive-cancer—a case series
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9751951/
https://www.ncbi.nlm.nih.gov/pubmed/36530632
http://dx.doi.org/10.3389/fneur.2022.1071519
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