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475. Does Metabolite Matter? Defining Target Itraconazole and Hydroxy-itraconazole Serum Levels for Blastomycosis

BACKGROUND: Itraconazole is first-line treatment for mild-moderate blastomycosis and consolidation of moderate-severe disease. Itraconazole is metabolized to 3 metabolites, including an active metabolite hydroxy-itraconazole. The sum of itraconazole and hydroxy-itraconazole levels > 1.0 mcg/mL is...

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Detalles Bibliográficos
Autores principales:	Hess, Danielle, Abu Saleh, Omar M, Enzler, Mark, Jannetto, Paul J, Mara, Kristin, Stevens, Ryan W, Vergidis, Paschalis, Rivera, Christina G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752264/ http://dx.doi.org/10.1093/ofid/ofac492.533

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