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1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center

BACKGROUND: SARS-CoV-2 B.1.1.529 (Omicron) variant was first identified in November 2021 in South Africa and was notable for its increased transmissibility and rapid spread worldwide. In the United States, this variant led to a surge in COVID-19 cases by December 2021. As a result, we experienced a...

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Autores principales: Dib, Rita Wilson, Spallone, Amy, Khawaja, Fareed, Bartek, Jalen, Cantu, Sherry, Dvorak, Tanya, Feldman, Adina, McMurry, Hilary, Nahavandi, Leila, Nguyen, Kim, Odom, Crystal, Hankins, Amy, Gravis, Linda, Chemaly, Roy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752466/
http://dx.doi.org/10.1093/ofid/ofac492.1541
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author Dib, Rita Wilson
Spallone, Amy
Khawaja, Fareed
Bartek, Jalen
Cantu, Sherry
Dvorak, Tanya
Feldman, Adina
McMurry, Hilary
Nahavandi, Leila
Nguyen, Kim
Odom, Crystal
Hankins, Amy
Gravis, Linda
Chemaly, Roy F
author_facet Dib, Rita Wilson
Spallone, Amy
Khawaja, Fareed
Bartek, Jalen
Cantu, Sherry
Dvorak, Tanya
Feldman, Adina
McMurry, Hilary
Nahavandi, Leila
Nguyen, Kim
Odom, Crystal
Hankins, Amy
Gravis, Linda
Chemaly, Roy F
author_sort Dib, Rita Wilson
collection PubMed
description BACKGROUND: SARS-CoV-2 B.1.1.529 (Omicron) variant was first identified in November 2021 in South Africa and was notable for its increased transmissibility and rapid spread worldwide. In the United States, this variant led to a surge in COVID-19 cases by December 2021. As a result, we experienced a steep rise in cases among patients and employees at our institution starting December 22nd, 2021. Therefore, we compared the incidence and characteristics of hospital-onset COVID-19 (HO-COVID-19) in our cancer patients prior to and during the surge of the Omicron variant. METHODS: We identified HO-COVID-19, as per the CDC definition, from our infection control surveillance database, and additional contact tracing information was reviewed to determine the possible sources of HO-COVID-19. Whole-genome sequencing studies were conducted randomly on nasopharyngeal swabs of patients and employees who had COVID-19 during the study period. RESULTS: Twenty-six HO-COVID-19 infections were identified from the beginning of the pandemic (February 2020) through February 2022 (Table 1). Only 17 cases occurred over 22 months from the beginning of the pandemic through early December 2021 (Figure 1). These HO-COVID-19 occurred during the 3 COVID-19 surges that were epidemiologically attributed to the variants seen prior to Omicron. Among these 17 patients, 12 (70%) were symptomatic, 9 (53%) had a link to an infected employee, 7 (41%) died during their hospitalization (3 of the deaths were attributable to COVID-19), and 10 (59%) recovered and were discharged. Over 6 weeks (from December 22nd, 2021, through February 1st, 2022), 9 HO-COVID-19 were discovered during the Omicron variant surge (Figure 1). Six (67%) of these patients were symptomatic, 8 (89%) had a link to an infected employee, 2 (22%) died (1 death was attributed to COVID-19 ), and 7 (78%) recovered and were discharged. [Figure: see text] [Figure: see text] CONCLUSION: The Omicron variant surge led to marked increases in HO-COVID-19 despite the continuous adoption of enhanced infection control practices, testing on admission, and daily symptoms screening of patients and employees. DISCLOSURES: Roy F. Chemaly, MD/MPH, Karius: Advisor/Consultant|Karius: Grant/Research Support.
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spelling pubmed-97524662022-12-16 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center Dib, Rita Wilson Spallone, Amy Khawaja, Fareed Bartek, Jalen Cantu, Sherry Dvorak, Tanya Feldman, Adina McMurry, Hilary Nahavandi, Leila Nguyen, Kim Odom, Crystal Hankins, Amy Gravis, Linda Chemaly, Roy F Open Forum Infect Dis Abstracts BACKGROUND: SARS-CoV-2 B.1.1.529 (Omicron) variant was first identified in November 2021 in South Africa and was notable for its increased transmissibility and rapid spread worldwide. In the United States, this variant led to a surge in COVID-19 cases by December 2021. As a result, we experienced a steep rise in cases among patients and employees at our institution starting December 22nd, 2021. Therefore, we compared the incidence and characteristics of hospital-onset COVID-19 (HO-COVID-19) in our cancer patients prior to and during the surge of the Omicron variant. METHODS: We identified HO-COVID-19, as per the CDC definition, from our infection control surveillance database, and additional contact tracing information was reviewed to determine the possible sources of HO-COVID-19. Whole-genome sequencing studies were conducted randomly on nasopharyngeal swabs of patients and employees who had COVID-19 during the study period. RESULTS: Twenty-six HO-COVID-19 infections were identified from the beginning of the pandemic (February 2020) through February 2022 (Table 1). Only 17 cases occurred over 22 months from the beginning of the pandemic through early December 2021 (Figure 1). These HO-COVID-19 occurred during the 3 COVID-19 surges that were epidemiologically attributed to the variants seen prior to Omicron. Among these 17 patients, 12 (70%) were symptomatic, 9 (53%) had a link to an infected employee, 7 (41%) died during their hospitalization (3 of the deaths were attributable to COVID-19), and 10 (59%) recovered and were discharged. Over 6 weeks (from December 22nd, 2021, through February 1st, 2022), 9 HO-COVID-19 were discovered during the Omicron variant surge (Figure 1). Six (67%) of these patients were symptomatic, 8 (89%) had a link to an infected employee, 2 (22%) died (1 death was attributed to COVID-19 ), and 7 (78%) recovered and were discharged. [Figure: see text] [Figure: see text] CONCLUSION: The Omicron variant surge led to marked increases in HO-COVID-19 despite the continuous adoption of enhanced infection control practices, testing on admission, and daily symptoms screening of patients and employees. DISCLOSURES: Roy F. Chemaly, MD/MPH, Karius: Advisor/Consultant|Karius: Grant/Research Support. Oxford University Press 2022-12-15 /pmc/articles/PMC9752466/ http://dx.doi.org/10.1093/ofid/ofac492.1541 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Dib, Rita Wilson
Spallone, Amy
Khawaja, Fareed
Bartek, Jalen
Cantu, Sherry
Dvorak, Tanya
Feldman, Adina
McMurry, Hilary
Nahavandi, Leila
Nguyen, Kim
Odom, Crystal
Hankins, Amy
Gravis, Linda
Chemaly, Roy F
1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title_full 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title_fullStr 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title_full_unstemmed 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title_short 1914. Characteristics of Hospital Onset SARS Cov-2 Infections Before and After the Emergence of The Highly Transmissible Variant B.1.1.529 In a Comprehensive Cancer Center
title_sort 1914. characteristics of hospital onset sars cov-2 infections before and after the emergence of the highly transmissible variant b.1.1.529 in a comprehensive cancer center
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752466/
http://dx.doi.org/10.1093/ofid/ofac492.1541
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