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1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint

BACKGROUND: Enterococci are the third most common hospital-acquired infection responsible for high morbidity and mortality, and are associated with high-grade vascular infections like infective endocarditis (IE). Our objective of the study is to discuss the outcomes of IE among patients with Enteroc...

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Autores principales: Patel, Premalkumar M, Ostran, Garrett Van, Camps, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752471/
http://dx.doi.org/10.1093/ofid/ofac492.1476
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author Patel, Premalkumar M
Ostran, Garrett Van
Camps, Nicholas
author_facet Patel, Premalkumar M
Ostran, Garrett Van
Camps, Nicholas
author_sort Patel, Premalkumar M
collection PubMed
description BACKGROUND: Enterococci are the third most common hospital-acquired infection responsible for high morbidity and mortality, and are associated with high-grade vascular infections like infective endocarditis (IE). Our objective of the study is to discuss the outcomes of IE among patients with Enterococcus Bacteremia (EB) using ICD-10 CM codes from the national database. METHODS: We conducted a retrospective cohort study using the publicly accessible National Inpatient Sample (NIS) database from October 2015 to December 2017. Adult patients ( >/=18), who developed EB were included in the study. SAS 9.4 was used for univariate and multivariate logistic regression analyses. RESULTS: There were a total of 75,465 patients included in the study who developed EB, among them 5440 (7.21%) patients with IE. In this cohort, 3,620 were males and 1,820 females, among them 3,955 (68.2%) were Caucasians, 620 (11.7%) were African Americans, 6,445 (8.80%) were Hispanic, 100 (1.9%) were Asian and 285 (5.4 %) were native Americans with IE. The majority of them were suffering from congestive heart failure (39.0%), valvular disease (22.0%), peripheral vascular disease (14.8%), chronic lung disease (16%) neurological complications (9.2%), diabetes mellitus with complications (13%) renal failure (32%), obesity (11.0%), and/or drug abuse (8%). In-hospital mortality was 13.7% (p< 0.0001), which was most likely due to the underlying co-morbidities, with an average length of stay of 15.8 (7-18) days and an economic burden of 48,850.3 (16,104–54,410) USD in comparison to patients without IE, who had in-hospital mortality 10.9%, average length of stay 13.6 (5-15) days, and economic burden 49,638 (11009-36665) USD. Age-adjusted mortality among the patients with Infective Endocarditis was 1.2 (1.07-1.28). CONCLUSION: Based on the results from our study, we found that patients with enterococcus bacteremia in appropriate settings should be screened for infective endocarditis to decrease the in-hospital mortality, length of stay, and economic burden. DISCLOSURES: All Authors: No reported disclosures.
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spelling pubmed-97524712022-12-16 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint Patel, Premalkumar M Ostran, Garrett Van Camps, Nicholas Open Forum Infect Dis Abstracts BACKGROUND: Enterococci are the third most common hospital-acquired infection responsible for high morbidity and mortality, and are associated with high-grade vascular infections like infective endocarditis (IE). Our objective of the study is to discuss the outcomes of IE among patients with Enterococcus Bacteremia (EB) using ICD-10 CM codes from the national database. METHODS: We conducted a retrospective cohort study using the publicly accessible National Inpatient Sample (NIS) database from October 2015 to December 2017. Adult patients ( >/=18), who developed EB were included in the study. SAS 9.4 was used for univariate and multivariate logistic regression analyses. RESULTS: There were a total of 75,465 patients included in the study who developed EB, among them 5440 (7.21%) patients with IE. In this cohort, 3,620 were males and 1,820 females, among them 3,955 (68.2%) were Caucasians, 620 (11.7%) were African Americans, 6,445 (8.80%) were Hispanic, 100 (1.9%) were Asian and 285 (5.4 %) were native Americans with IE. The majority of them were suffering from congestive heart failure (39.0%), valvular disease (22.0%), peripheral vascular disease (14.8%), chronic lung disease (16%) neurological complications (9.2%), diabetes mellitus with complications (13%) renal failure (32%), obesity (11.0%), and/or drug abuse (8%). In-hospital mortality was 13.7% (p< 0.0001), which was most likely due to the underlying co-morbidities, with an average length of stay of 15.8 (7-18) days and an economic burden of 48,850.3 (16,104–54,410) USD in comparison to patients without IE, who had in-hospital mortality 10.9%, average length of stay 13.6 (5-15) days, and economic burden 49,638 (11009-36665) USD. Age-adjusted mortality among the patients with Infective Endocarditis was 1.2 (1.07-1.28). CONCLUSION: Based on the results from our study, we found that patients with enterococcus bacteremia in appropriate settings should be screened for infective endocarditis to decrease the in-hospital mortality, length of stay, and economic burden. DISCLOSURES: All Authors: No reported disclosures. Oxford University Press 2022-12-15 /pmc/articles/PMC9752471/ http://dx.doi.org/10.1093/ofid/ofac492.1476 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Patel, Premalkumar M
Ostran, Garrett Van
Camps, Nicholas
1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title_full 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title_fullStr 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title_full_unstemmed 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title_short 1847. Overview of Infective Endocarditis in Patients with Enterococcus Bacteremia from National Standpoint
title_sort 1847. overview of infective endocarditis in patients with enterococcus bacteremia from national standpoint
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752471/
http://dx.doi.org/10.1093/ofid/ofac492.1476
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