Cargando…
2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities
BACKGROUND: Healthcare workers (HCWs) are at heightened risk of exposure to respiratory pathogens, and occupy an important epidemiologic position in the COVID-19 pandemic. PAIVED, a multicenter, multiservice study assessing influenza vaccine effectiveness in the Department of Defense over four conse...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752492/ http://dx.doi.org/10.1093/ofid/ofac492.1819 |
_version_ | 1784850737156587520 |
---|---|
author | Liberg, Ryan Schofield, Christina Richard, Stephanie A Collins, Limone Spooner, Christina Seshadri, Srihari Ganesan, Anuradha Campbell, Wesley R Hrncir, David Lalani, Tahaniyat Warkentien, Tyler Mende, Katrin Markelz, Ana E Berjohn, Catherine M McClenathan, Bruce Modi, Jitendrakumar Williams, Alan Burgess, Timothy Colombo, Rhonda E |
author_facet | Liberg, Ryan Schofield, Christina Richard, Stephanie A Collins, Limone Spooner, Christina Seshadri, Srihari Ganesan, Anuradha Campbell, Wesley R Hrncir, David Lalani, Tahaniyat Warkentien, Tyler Mende, Katrin Markelz, Ana E Berjohn, Catherine M McClenathan, Bruce Modi, Jitendrakumar Williams, Alan Burgess, Timothy Colombo, Rhonda E |
author_sort | Liberg, Ryan |
collection | PubMed |
description | BACKGROUND: Healthcare workers (HCWs) are at heightened risk of exposure to respiratory pathogens, and occupy an important epidemiologic position in the COVID-19 pandemic. PAIVED, a multicenter, multiservice study assessing influenza vaccine effectiveness in the Department of Defense over four consecutive influenza seasons (2018-22), provides an opportunity to describe influenza like illness (ILI) experience and assess the impact of SARS-CoV-2 in HCWs compared to non-HCWs. METHODS: PAIVED participants were randomized to receive either egg-based, cell-based, or recombinant-derived influenza vaccine and then surveyed weekly for ILI. At enrollment, participants provided key demographic data including whether they were HCWs with direct patient contact. ILI was defined a priori as 1) having cough or sore throat plus 2) feeling feverish/having chills or having body aches/fatigue. Participants with ILI completed a symptom diary for seven days and submitted a nasal swab for pathogen detection. Study recruitment was conducted from September-January over four consecutive years. RESULTS: Of 13188 eligible participants enrolled, 4819 (36%) were HCWs. Overall, HCWs were more likely to be female (43% vs 31%), active duty military (86% vs 69%), and to identify as white (61% vs 56%). HCWs more commonly reported ILI than non-HCWs (25% vs 21%, p< 0.01). Of those experiencing ILI, SARS-CoV-2 was identified in a higher proportion of HCWs than non-HCWs (17% vs 12%, p< 0.01). Influenza was isolated in similar proportion of HCWs and non-HCWs (5% vs 4%). Each group reported similar ILI duration and severity (p< 0.01). CONCLUSION: In a prior analysis of the 2019-20 PAIVED season, HCWs were more likely than non-HCWs to report ILI, have shorter illness duration, and isolate influenza A (H1N1). The propensity for HCWs to report ILI persisted over the four years. While SARS-CoV-2 emerged as a major pathogen in both groups, HCWs were more likely to have it identified as a cause of ILI, suggesting increased risk of symptomatic SARS-CoV-2 in our HCW population. Influenza incidence was lower than that of SARS-COV-2, and did not differ between HCWs and non-HCWs. Mean duration of illness did not differ between groups over four years; this equalization may relate to the higher incidence of SARS-CoV-2 in HCWs. DISCLOSURES: Jitendrakumar Modi, MD, GlaxoSmithKline: I am a paid speaker for GSK. I do not speak for their flu brand. Timothy Burgess, MD, MPH, AstraZeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response. |
format | Online Article Text |
id | pubmed-9752492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97524922022-12-16 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities Liberg, Ryan Schofield, Christina Richard, Stephanie A Collins, Limone Spooner, Christina Seshadri, Srihari Ganesan, Anuradha Campbell, Wesley R Hrncir, David Lalani, Tahaniyat Warkentien, Tyler Mende, Katrin Markelz, Ana E Berjohn, Catherine M McClenathan, Bruce Modi, Jitendrakumar Williams, Alan Burgess, Timothy Colombo, Rhonda E Open Forum Infect Dis Abstracts BACKGROUND: Healthcare workers (HCWs) are at heightened risk of exposure to respiratory pathogens, and occupy an important epidemiologic position in the COVID-19 pandemic. PAIVED, a multicenter, multiservice study assessing influenza vaccine effectiveness in the Department of Defense over four consecutive influenza seasons (2018-22), provides an opportunity to describe influenza like illness (ILI) experience and assess the impact of SARS-CoV-2 in HCWs compared to non-HCWs. METHODS: PAIVED participants were randomized to receive either egg-based, cell-based, or recombinant-derived influenza vaccine and then surveyed weekly for ILI. At enrollment, participants provided key demographic data including whether they were HCWs with direct patient contact. ILI was defined a priori as 1) having cough or sore throat plus 2) feeling feverish/having chills or having body aches/fatigue. Participants with ILI completed a symptom diary for seven days and submitted a nasal swab for pathogen detection. Study recruitment was conducted from September-January over four consecutive years. RESULTS: Of 13188 eligible participants enrolled, 4819 (36%) were HCWs. Overall, HCWs were more likely to be female (43% vs 31%), active duty military (86% vs 69%), and to identify as white (61% vs 56%). HCWs more commonly reported ILI than non-HCWs (25% vs 21%, p< 0.01). Of those experiencing ILI, SARS-CoV-2 was identified in a higher proportion of HCWs than non-HCWs (17% vs 12%, p< 0.01). Influenza was isolated in similar proportion of HCWs and non-HCWs (5% vs 4%). Each group reported similar ILI duration and severity (p< 0.01). CONCLUSION: In a prior analysis of the 2019-20 PAIVED season, HCWs were more likely than non-HCWs to report ILI, have shorter illness duration, and isolate influenza A (H1N1). The propensity for HCWs to report ILI persisted over the four years. While SARS-CoV-2 emerged as a major pathogen in both groups, HCWs were more likely to have it identified as a cause of ILI, suggesting increased risk of symptomatic SARS-CoV-2 in our HCW population. Influenza incidence was lower than that of SARS-COV-2, and did not differ between HCWs and non-HCWs. Mean duration of illness did not differ between groups over four years; this equalization may relate to the higher incidence of SARS-CoV-2 in HCWs. DISCLOSURES: Jitendrakumar Modi, MD, GlaxoSmithKline: I am a paid speaker for GSK. I do not speak for their flu brand. Timothy Burgess, MD, MPH, AstraZeneca: The HJF, in support of the USU IDCRP, was funded to conduct or augment unrelated Phase III Mab and vaccine trials as part of US Govt. COVID19 response. Oxford University Press 2022-12-15 /pmc/articles/PMC9752492/ http://dx.doi.org/10.1093/ofid/ofac492.1819 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Liberg, Ryan Schofield, Christina Richard, Stephanie A Collins, Limone Spooner, Christina Seshadri, Srihari Ganesan, Anuradha Campbell, Wesley R Hrncir, David Lalani, Tahaniyat Warkentien, Tyler Mende, Katrin Markelz, Ana E Berjohn, Catherine M McClenathan, Bruce Modi, Jitendrakumar Williams, Alan Burgess, Timothy Colombo, Rhonda E 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title | 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title_full | 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title_fullStr | 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title_full_unstemmed | 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title_short | 2200. Impact of COVID-19 Pandemic on Influenza-like Illness (ILI) Experience among Healthcare Workers in Military Treatment Facilities |
title_sort | 2200. impact of covid-19 pandemic on influenza-like illness (ili) experience among healthcare workers in military treatment facilities |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752492/ http://dx.doi.org/10.1093/ofid/ofac492.1819 |
work_keys_str_mv | AT libergryan 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT schofieldchristina 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT richardstephaniea 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT collinslimone 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT spoonerchristina 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT seshadrisrihari 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT ganesananuradha 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT campbellwesleyr 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT hrncirdavid 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT lalanitahaniyat 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT warkentientyler 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT mendekatrin 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT markelzanae 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT berjohncatherinem 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT mcclenathanbruce 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT modijitendrakumar 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT williamsalan 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT burgesstimothy 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities AT colomborhondae 2200impactofcovid19pandemiconinfluenzalikeillnessiliexperienceamonghealthcareworkersinmilitarytreatmentfacilities |