1960. Mucosal rAd5 Immunization against SARS-CoV-2 Spike Elicits Cross-Reactive Nasal and Serum Neutralizing Antibodies and Protects Against Beta Variant Challenge in African Green Monkeys

BACKGROUND: Mucosal vaccination may offer increased protection against SARS-CoV-2 compared to parental immunization. Here, we describe immunogenicity and efficacy following viral challenge in non-human primates after intranasal delivery of three unique non-replicating adenoviral vector vaccine (rAd5...

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Autores principales: Flitter, Becca A, Tedjakusuma, Sarah N, Lester, Colin A, Neuhaus, Elena D, Johnson, Susan, Dora, Emery G, Peinovich, Nadine, Jegede, Clara B, Tucker, Sean N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
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Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752514/
http://dx.doi.org/10.1093/ofid/ofac492.1586

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