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Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases

Aquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive...

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Autores principales: Huang, Yuchan, Yan, Shidu, Su, Zixia, Xia, Lei, Xie, Jinling, Zhang, Fan, Du, Zhengcai, Hou, Xiaotao, Deng, Jiagang, Hao, Erwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752864/
https://www.ncbi.nlm.nih.gov/pubmed/36532729
http://dx.doi.org/10.3389/fphar.2022.1069310
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author Huang, Yuchan
Yan, Shidu
Su, Zixia
Xia, Lei
Xie, Jinling
Zhang, Fan
Du, Zhengcai
Hou, Xiaotao
Deng, Jiagang
Hao, Erwei
author_facet Huang, Yuchan
Yan, Shidu
Su, Zixia
Xia, Lei
Xie, Jinling
Zhang, Fan
Du, Zhengcai
Hou, Xiaotao
Deng, Jiagang
Hao, Erwei
author_sort Huang, Yuchan
collection PubMed
description Aquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive system and have important implications for the physiopathology of the gastrointestinal tract as well as other tissues and organs. AQP regulators can prevent and treat most gastrointestinal-related diseases, such as colorectal cancer, gastric ulcer, and gastric cancer. Although recent studies have proposed clinically relevant AQP-targeted therapies, such as the development of AQP inhibitors, clinical trials are still lacking and there are many difficulties. Traditional Chinese medicine (TCM) has been used in China for thousands of years to prevent, treat and diagnose diseases, and is under the guidance of Chinese medicine (CM) theory. Herein, we review the latest research on the regulation of AQPs by TCMs and their active components, including Rhei Radix et Rhizoma, Atractylodis macrocephalae Rhizoma, Salviae miltiorrhizae Radix et Rhizoma, Poria, Astragali radix, and another 26 TCMs, as well as active components, which include the active components include anthraquinones, saponins, polysaccharides, and flavonoid glycosides. Through our review and discussion of numerous studies, we attempt to explore the regulatory effects of TCMs and their active components on AQP expression in the corresponding parts of the body in terms of the Triple Energizer concept in Chinese medicine defined as “upper energizer, middle energizer, and lower energizer,”so as to offer unique opportunities for the development of AQP-related therapeutic drugs for digestive system diseases.
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spelling pubmed-97528642022-12-16 Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases Huang, Yuchan Yan, Shidu Su, Zixia Xia, Lei Xie, Jinling Zhang, Fan Du, Zhengcai Hou, Xiaotao Deng, Jiagang Hao, Erwei Front Pharmacol Pharmacology Aquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive system and have important implications for the physiopathology of the gastrointestinal tract as well as other tissues and organs. AQP regulators can prevent and treat most gastrointestinal-related diseases, such as colorectal cancer, gastric ulcer, and gastric cancer. Although recent studies have proposed clinically relevant AQP-targeted therapies, such as the development of AQP inhibitors, clinical trials are still lacking and there are many difficulties. Traditional Chinese medicine (TCM) has been used in China for thousands of years to prevent, treat and diagnose diseases, and is under the guidance of Chinese medicine (CM) theory. Herein, we review the latest research on the regulation of AQPs by TCMs and their active components, including Rhei Radix et Rhizoma, Atractylodis macrocephalae Rhizoma, Salviae miltiorrhizae Radix et Rhizoma, Poria, Astragali radix, and another 26 TCMs, as well as active components, which include the active components include anthraquinones, saponins, polysaccharides, and flavonoid glycosides. Through our review and discussion of numerous studies, we attempt to explore the regulatory effects of TCMs and their active components on AQP expression in the corresponding parts of the body in terms of the Triple Energizer concept in Chinese medicine defined as “upper energizer, middle energizer, and lower energizer,”so as to offer unique opportunities for the development of AQP-related therapeutic drugs for digestive system diseases. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9752864/ /pubmed/36532729 http://dx.doi.org/10.3389/fphar.2022.1069310 Text en Copyright © 2022 Huang, Yan, Su, Xia, Xie, Zhang, Du, Hou, Deng and Hao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Huang, Yuchan
Yan, Shidu
Su, Zixia
Xia, Lei
Xie, Jinling
Zhang, Fan
Du, Zhengcai
Hou, Xiaotao
Deng, Jiagang
Hao, Erwei
Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title_full Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title_fullStr Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title_full_unstemmed Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title_short Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases
title_sort aquaporins: a new target for traditional chinese medicine in the treatment of digestive system diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752864/
https://www.ncbi.nlm.nih.gov/pubmed/36532729
http://dx.doi.org/10.3389/fphar.2022.1069310
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