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782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)

BACKGROUND: More than 200 orthotopic lung transplants (OLT) have been performed in the United States for patients (pts) with severe CALI. While some outcomes have been reported to generally be good, we conducted this study to describe the infectious outcomes. METHODS: After IRB approval, a retrospec...

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Autores principales: Osborn, Rebecca, Ison, Michael G, Alamri, Maha M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752895/
http://dx.doi.org/10.1093/ofid/ofac492.043
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author Osborn, Rebecca
Ison, Michael G
Alamri, Maha M
author_facet Osborn, Rebecca
Ison, Michael G
Alamri, Maha M
author_sort Osborn, Rebecca
collection PubMed
description BACKGROUND: More than 200 orthotopic lung transplants (OLT) have been performed in the United States for patients (pts) with severe CALI. While some outcomes have been reported to generally be good, we conducted this study to describe the infectious outcomes. METHODS: After IRB approval, a retrospective case review was conducted of pts at Northwestern Memorial Hospital who had undergone OLT for CALI between June 1, 2020 and January 31, 2022. Data was collected from our Enterprise Data Warehouse and primary chart review to describe pts demographics and epidemiology of infectious complications. RESULTS: 35 OLTs were included (33 bilateral, 2 single lung; see Table 1). In the two weeks prior to transplant, 65.7% of pts were treated for bacterial, fungal, or mycobacterial infections (Table 2). Post-transplant, 32 (91.4%) of OLTs developed infections (Table 2), with most (28, 80%) developing pneumonia within 30 days of transplant. Five (14.3%) pts had airway complications, 7 (20%) pts required hemodialysis, and 3 (8.6%) pts died within one year of follow-up. [Figure: see text] [Figure: see text] CONCLUSION: Infections remain a significant cause of morbidity post-OLT for CALI. Enhanced immunosuppression, long ICU stays post-tx, high rates of primary graft dysfunction and deconditioning likely contributed to this high rate of infection. A matched control group is being collected to compare these outcomes to other OLT pts. DISCLOSURES: Michael G. Ison, MD MS, GlaxoSmithKline: Advisor/Consultant|GlaxoSmithKline: Grant/Research Support.
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spelling pubmed-97528952022-12-16 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI) Osborn, Rebecca Ison, Michael G Alamri, Maha M Open Forum Infect Dis Abstracts BACKGROUND: More than 200 orthotopic lung transplants (OLT) have been performed in the United States for patients (pts) with severe CALI. While some outcomes have been reported to generally be good, we conducted this study to describe the infectious outcomes. METHODS: After IRB approval, a retrospective case review was conducted of pts at Northwestern Memorial Hospital who had undergone OLT for CALI between June 1, 2020 and January 31, 2022. Data was collected from our Enterprise Data Warehouse and primary chart review to describe pts demographics and epidemiology of infectious complications. RESULTS: 35 OLTs were included (33 bilateral, 2 single lung; see Table 1). In the two weeks prior to transplant, 65.7% of pts were treated for bacterial, fungal, or mycobacterial infections (Table 2). Post-transplant, 32 (91.4%) of OLTs developed infections (Table 2), with most (28, 80%) developing pneumonia within 30 days of transplant. Five (14.3%) pts had airway complications, 7 (20%) pts required hemodialysis, and 3 (8.6%) pts died within one year of follow-up. [Figure: see text] [Figure: see text] CONCLUSION: Infections remain a significant cause of morbidity post-OLT for CALI. Enhanced immunosuppression, long ICU stays post-tx, high rates of primary graft dysfunction and deconditioning likely contributed to this high rate of infection. A matched control group is being collected to compare these outcomes to other OLT pts. DISCLOSURES: Michael G. Ison, MD MS, GlaxoSmithKline: Advisor/Consultant|GlaxoSmithKline: Grant/Research Support. Oxford University Press 2022-12-15 /pmc/articles/PMC9752895/ http://dx.doi.org/10.1093/ofid/ofac492.043 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Osborn, Rebecca
Ison, Michael G
Alamri, Maha M
782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title_full 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title_fullStr 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title_full_unstemmed 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title_short 782. Infectious Complications of Lung Transplant for COVID-Associated Lung Injury (CALI)
title_sort 782. infectious complications of lung transplant for covid-associated lung injury (cali)
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752895/
http://dx.doi.org/10.1093/ofid/ofac492.043
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