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CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population

OBJECTIVES: Ischemic stroke (IS) is the major cause of death and disability. While previous studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to analyze the impact of CYP11B1 gene polymorphisms on the IS susceptibility. METHODS: The present study genotyped six sin...

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Autores principales: Liu, Gaowen, Duan, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752905/
https://www.ncbi.nlm.nih.gov/pubmed/36532271
http://dx.doi.org/10.3389/fnins.2022.1030551
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author Liu, Gaowen
Duan, Ying
author_facet Liu, Gaowen
Duan, Ying
author_sort Liu, Gaowen
collection PubMed
description OBJECTIVES: Ischemic stroke (IS) is the major cause of death and disability. While previous studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to analyze the impact of CYP11B1 gene polymorphisms on the IS susceptibility. METHODS: The present study genotyped six single nucleotide polymorphisms (SNPs) (including rs4736312, rs5017238, rs5301, rs5283, rs6410, and rs4534) of CYP11B1 in peripheral blood samples from IS and control populations. Logistic regression analysis was used to analyze the association between the SNPs and IS risk. The multifactor dimensionality reduction (MDR) method was used to determine the roles of SNP–SNP interactions in IS. RESULTS: The present study showed that rs5283 was associated with an increased susceptibility to IS [odds ratio (OR) 1.81, p = 0.012]. On the contrary, rs6410 had a protective influence on IS risk (OR 0.56, p = 0.020). Stratified analyses indicated that rs5283 could enhance the risk of IS in subjects aged >63 years (OR 2.41, p = 0.011), of female gender (OR 3.31, p = 0.001), that do not smoke (OR 1.64, p = 0.005), and with hypertension (OR 2.07, p = 0.003). Whereas, rs6410 was related to a lower susceptibility to IS in subjects aged >63 years (OR 0.43, p = 0.032), of female gender (OR 0.30, p = 0.006), do not smoke (OR 0.42, p = 0.017), and with hypertension (OR 0.52, p = 0.022). Besides, rs4736312 reduced the IS susceptibility in non-smokers (OR 0.69, p = 0.031). Rs4534 had a risk-decreasing impact on IS in non-drinking (OR 0.54, p = 0.016). Moreover, the results of the MDR analysis corroborate that the best prediction model for IS was rs5283. CONCLUSION: This study revealed that CYP11B1 gene polymorphisms strongly correlated with IS in the Chinese Han population.
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spelling pubmed-97529052022-12-16 CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population Liu, Gaowen Duan, Ying Front Neurosci Neuroscience OBJECTIVES: Ischemic stroke (IS) is the major cause of death and disability. While previous studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to analyze the impact of CYP11B1 gene polymorphisms on the IS susceptibility. METHODS: The present study genotyped six single nucleotide polymorphisms (SNPs) (including rs4736312, rs5017238, rs5301, rs5283, rs6410, and rs4534) of CYP11B1 in peripheral blood samples from IS and control populations. Logistic regression analysis was used to analyze the association between the SNPs and IS risk. The multifactor dimensionality reduction (MDR) method was used to determine the roles of SNP–SNP interactions in IS. RESULTS: The present study showed that rs5283 was associated with an increased susceptibility to IS [odds ratio (OR) 1.81, p = 0.012]. On the contrary, rs6410 had a protective influence on IS risk (OR 0.56, p = 0.020). Stratified analyses indicated that rs5283 could enhance the risk of IS in subjects aged >63 years (OR 2.41, p = 0.011), of female gender (OR 3.31, p = 0.001), that do not smoke (OR 1.64, p = 0.005), and with hypertension (OR 2.07, p = 0.003). Whereas, rs6410 was related to a lower susceptibility to IS in subjects aged >63 years (OR 0.43, p = 0.032), of female gender (OR 0.30, p = 0.006), do not smoke (OR 0.42, p = 0.017), and with hypertension (OR 0.52, p = 0.022). Besides, rs4736312 reduced the IS susceptibility in non-smokers (OR 0.69, p = 0.031). Rs4534 had a risk-decreasing impact on IS in non-drinking (OR 0.54, p = 0.016). Moreover, the results of the MDR analysis corroborate that the best prediction model for IS was rs5283. CONCLUSION: This study revealed that CYP11B1 gene polymorphisms strongly correlated with IS in the Chinese Han population. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9752905/ /pubmed/36532271 http://dx.doi.org/10.3389/fnins.2022.1030551 Text en Copyright © 2022 Liu and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Gaowen
Duan, Ying
CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title_full CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title_fullStr CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title_full_unstemmed CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title_short CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
title_sort cyp11b1 gene polymorphisms and susceptibility to ischemic stroke in a chinese han population
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752905/
https://www.ncbi.nlm.nih.gov/pubmed/36532271
http://dx.doi.org/10.3389/fnins.2022.1030551
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