1432. Exploring Cell Wall Targets to Overcome Mycobacterium tuberculosis (Mtb): Ceftriaxone (CRO) Inhibits Ldt(Mt2), a Major Peptidoglycan (PG) Synthase

BACKGROUND: Drug-resistant tuberculosis (DR TB) is a deadly, difficult-to-treat infection, and new treatment strategies are needed. Despite the wide success of β-lactams (BLs), DR TB guidelines only include meropenem (MEM) and imipenem (IPM), given with clavulanate (CLA). BlaC, the Mtb β-lactamase,...

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Detalles Bibliográficos
Autores principales: Nguyen, David C, Redmond, Sarah N, Dousa, Khalid M, Bethel, Christopher, Taracila, Magdalena A, Li, Qing, Kurz, Sebastian G, Pavelka, Martin S, Papp-Wallace, Krisztina, Holland, Steven M, Kreiswirth, Barry N, Boom, Henry, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752925/
http://dx.doi.org/10.1093/ofid/ofac492.1261

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