1704. Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, Demonstrates Potent Efficacy and Improves Efficacy of Standard of Care Regimen Against Mycobacterium avium complex in a Chronic Mouse Lung Infection Model

BACKGROUND: Epetraborole (EBO) is a boron-containing oral inhibitor of bacterial leucyl-tRNA synthetase, an essential enzyme in protein synthesis; EBO demonstrates potent activity against nontuberculous mycobacteria. These studies evaluated oral doses (PO) of EBO against 5 M. avium complex (MAC) str...

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Detalles Bibliográficos
Autores principales: De, Kavita, DeStefano, Michelle S, Shoen, Carolyn, Cynamon, Michael H, Alley, M R K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752932/
http://dx.doi.org/10.1093/ofid/ofac492.1334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9752932/
http://dx.doi.org/10.1093/ofid/ofac492.1334

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