Radotinib attenuates TGFβ -mediated pulmonary fibrosis in vitro and in vivo: exploring the potential of drug repurposing

BACKGROUND: Tyrosine kinase (TK) plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis. Here, we aimed to investigate whether radotinib (Rb) could inhibit pulmonary fibrosis by inhibiting TK in vitro and in vivo. METHODS: The antifibrotic effects of Rb in transforming growth fact...

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Detalles Bibliográficos
Autores principales: Baek, Suji, Kwon, Seung Hae, Jeon, Joo Yeong, Lee, Gong Yeal, Ju, Hyun Soo, Yun, Hyo Jung, Cho, Dae Jin, Lee, Kang Pa, Nam, Myung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753032/
https://www.ncbi.nlm.nih.gov/pubmed/36522756
http://dx.doi.org/10.1186/s40360-022-00634-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753032/
https://www.ncbi.nlm.nih.gov/pubmed/36522756
http://dx.doi.org/10.1186/s40360-022-00634-x

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