In Silico and Structure-Based Assessment of Similar Variants Discovered in Tandem Repeats of BRCT Domains of BRCA1 and BARD1 To Characterize the Folding Pattern

[Image: see text] BRCA1 and BARD1 are important proteins in the homologous DNA damage repair pathways. Different genetic variants identified in these proteins have been clinically correlated with the occurrence of hereditary breast and ovarian cancer (HBOC). Variants of unknown significance (VUS) re...

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Detalles Bibliográficos
Autores principales: Barua, Siddhartha A., Goswami, Nabajyoti, Mishra, Neha, Sawant, Ulka U., Varma, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753114/
https://www.ncbi.nlm.nih.gov/pubmed/36530327
http://dx.doi.org/10.1021/acsomega.2c04782

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