Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score

BACKGROUND: What combination of risk factors for Alzheimer’s disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype, AD-Polygenic Risk Scores (AD-PRS), amyloid-β pathology and decline in cogni...

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Detalles Bibliográficos
Autores principales: Tomassen, Jori, den Braber, Anouk, van der Lee, Sven J., Reus, Lianne M., Konijnenberg, Elles, Carter, Stephen F., Yaqub, Maqsood, van Berckel, Bart N.M., Collij, Lyduine E., Boomsma, Dorret I., de Geus, Eco J.C., Scheltens, Philip, Herholz, Karl, Tijms, Betty M., Visser, Pieter Jelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753236/
https://www.ncbi.nlm.nih.gov/pubmed/36522743
http://dx.doi.org/10.1186/s12883-022-02925-6

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