Cargando…

Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women

BACKGROUND: Hypertensive disorders of pregnancy including preexisting (or chronic) hypertension are the most common complication encountered during pregnancy that contribute significantly to maternal and perinatal morbidity and mortality. Brain natriuretic peptide (BNP) and copeptin have been invest...

Descripción completa

Detalles Bibliográficos
Autores principales: Okwor, Chika J., Adedapo, Kayode S., Bello, Oluwasomidoyin O., Meka, Ijeoma A., Okwor, Chukwuemeka V., Uche, Chukwuemelie Z., Nwajiobi, Chiebonam E., Nto-Ezimah, Uloaku A., Uchechukwu, Chisom E., Arum, Ekene J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753280/
https://www.ncbi.nlm.nih.gov/pubmed/36517833
http://dx.doi.org/10.1186/s40885-022-00221-6
_version_ 1784850930786631680
author Okwor, Chika J.
Adedapo, Kayode S.
Bello, Oluwasomidoyin O.
Meka, Ijeoma A.
Okwor, Chukwuemeka V.
Uche, Chukwuemelie Z.
Nwajiobi, Chiebonam E.
Nto-Ezimah, Uloaku A.
Uchechukwu, Chisom E.
Arum, Ekene J.
author_facet Okwor, Chika J.
Adedapo, Kayode S.
Bello, Oluwasomidoyin O.
Meka, Ijeoma A.
Okwor, Chukwuemeka V.
Uche, Chukwuemelie Z.
Nwajiobi, Chiebonam E.
Nto-Ezimah, Uloaku A.
Uchechukwu, Chisom E.
Arum, Ekene J.
author_sort Okwor, Chika J.
collection PubMed
description BACKGROUND: Hypertensive disorders of pregnancy including preexisting (or chronic) hypertension are the most common complication encountered during pregnancy that contribute significantly to maternal and perinatal morbidity and mortality. Brain natriuretic peptide (BNP) and copeptin have been investigated as biomarkers in various hypertensive disorders, but studies of their clinical value in chronic hypertensive pregnant women are sparce. This study aimed to assess the levels of BNP and copeptin in chronic hypertensive pregnant women and investigate their correlation with blood pressure (BP) in chronic hypertensive pregnant women in South Western Nigeria. METHODS: One hundred and sixty consenting pregnant women in their third trimester of pregnancy, grouped into those with chronic hypertension (n = 80) and normotensive (n = 80), were recruited for this cross-sectional study. Age and clinical characteristics were obtained, and blood was aseptically drawn for BNP and copeptin measurement using enzyme-linked immunosorbent assay. Data was analyzed with IBM SPSS ver. 20.0. Data was analyzed using Student t-test, chi-square, and Pearson correlation test as appropriate. Statistical significance was set at P < 0.05. RESULTS: The mean systolic BP (SBP) and diastolic BP (DBP) were significantly higher in pregnant women with chronic hypertension (158.30 ± 3.51 and 105.08 ± 2.47 mmHg, respectively) compared with normotensive pregnant women (100.72 ± 3.02 and 70.29 ± 1.96 mmHg, respectively). The mean levels of BNP and copeptin were higher in pregnant women with chronic hypertension (57.26 ± 3.65 pg/mL and 12.44 ± 1.02 pmol/L, respectively) compared with normotensive pregnant women (49.85 ± 2.44 pg/mL and 10.25 ± 1.50 pmol/L, respectively) though not statistically significant. Correlations observed between SBP and DBP with levels of BNP (r = 0.204, P = 0.200; r = 0.142, P = 0.478) and copeptin (r = − 0.058, P = 0.288; r = 0.045, P = 0.907) were not statistically significant. CONCLUSIONS: There was no association between BP and the levels of BNP and copeptin in pregnant women with chronic hypertension who were already on antihypertensive treatment, with the implication that antihypertensive treatment may modulate BNP and copeptin release despite significantly elevated BP levels.
format Online
Article
Text
id pubmed-9753280
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-97532802022-12-16 Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women Okwor, Chika J. Adedapo, Kayode S. Bello, Oluwasomidoyin O. Meka, Ijeoma A. Okwor, Chukwuemeka V. Uche, Chukwuemelie Z. Nwajiobi, Chiebonam E. Nto-Ezimah, Uloaku A. Uchechukwu, Chisom E. Arum, Ekene J. Clin Hypertens Research BACKGROUND: Hypertensive disorders of pregnancy including preexisting (or chronic) hypertension are the most common complication encountered during pregnancy that contribute significantly to maternal and perinatal morbidity and mortality. Brain natriuretic peptide (BNP) and copeptin have been investigated as biomarkers in various hypertensive disorders, but studies of their clinical value in chronic hypertensive pregnant women are sparce. This study aimed to assess the levels of BNP and copeptin in chronic hypertensive pregnant women and investigate their correlation with blood pressure (BP) in chronic hypertensive pregnant women in South Western Nigeria. METHODS: One hundred and sixty consenting pregnant women in their third trimester of pregnancy, grouped into those with chronic hypertension (n = 80) and normotensive (n = 80), were recruited for this cross-sectional study. Age and clinical characteristics were obtained, and blood was aseptically drawn for BNP and copeptin measurement using enzyme-linked immunosorbent assay. Data was analyzed with IBM SPSS ver. 20.0. Data was analyzed using Student t-test, chi-square, and Pearson correlation test as appropriate. Statistical significance was set at P < 0.05. RESULTS: The mean systolic BP (SBP) and diastolic BP (DBP) were significantly higher in pregnant women with chronic hypertension (158.30 ± 3.51 and 105.08 ± 2.47 mmHg, respectively) compared with normotensive pregnant women (100.72 ± 3.02 and 70.29 ± 1.96 mmHg, respectively). The mean levels of BNP and copeptin were higher in pregnant women with chronic hypertension (57.26 ± 3.65 pg/mL and 12.44 ± 1.02 pmol/L, respectively) compared with normotensive pregnant women (49.85 ± 2.44 pg/mL and 10.25 ± 1.50 pmol/L, respectively) though not statistically significant. Correlations observed between SBP and DBP with levels of BNP (r = 0.204, P = 0.200; r = 0.142, P = 0.478) and copeptin (r = − 0.058, P = 0.288; r = 0.045, P = 0.907) were not statistically significant. CONCLUSIONS: There was no association between BP and the levels of BNP and copeptin in pregnant women with chronic hypertension who were already on antihypertensive treatment, with the implication that antihypertensive treatment may modulate BNP and copeptin release despite significantly elevated BP levels. BioMed Central 2022-12-15 /pmc/articles/PMC9753280/ /pubmed/36517833 http://dx.doi.org/10.1186/s40885-022-00221-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Okwor, Chika J.
Adedapo, Kayode S.
Bello, Oluwasomidoyin O.
Meka, Ijeoma A.
Okwor, Chukwuemeka V.
Uche, Chukwuemelie Z.
Nwajiobi, Chiebonam E.
Nto-Ezimah, Uloaku A.
Uchechukwu, Chisom E.
Arum, Ekene J.
Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title_full Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title_fullStr Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title_full_unstemmed Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title_short Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
title_sort assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753280/
https://www.ncbi.nlm.nih.gov/pubmed/36517833
http://dx.doi.org/10.1186/s40885-022-00221-6
work_keys_str_mv AT okworchikaj assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT adedapokayodes assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT bellooluwasomidoyino assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT mekaijeomaa assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT okworchukwuemekav assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT uchechukwuemeliez assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT nwajiobichieboname assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT ntoezimahuloakua assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT uchechukwuchisome assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen
AT arumekenej assessmentofbrainnatriureticpeptideandcopeptinascorrelatesofbloodpressureinchronichypertensivepregnantwomen