MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings

Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–de...

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Detalles Bibliográficos
Autores principales: Hurtubise, Brigitte, Frohman, Elliot M., Galetta, Steven, Balcer, Laura J., Frohman, Teresa C., Lisak, Robert P., Newsome, Scott D., Graves, Jennifer S., Zamvil, Scott S., Amezcua, Lilyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Diagnostic & Treatment Challenges
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753285/
https://www.ncbi.nlm.nih.gov/pubmed/36517233
http://dx.doi.org/10.1212/NXI.0000000000200077
Descripción
Sumario:Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.

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