MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings

Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–de...

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Autores principales: Hurtubise, Brigitte, Frohman, Elliot M., Galetta, Steven, Balcer, Laura J., Frohman, Teresa C., Lisak, Robert P., Newsome, Scott D., Graves, Jennifer S., Zamvil, Scott S., Amezcua, Lilyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Diagnostic & Treatment Challenges
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753285/
https://www.ncbi.nlm.nih.gov/pubmed/36517233
http://dx.doi.org/10.1212/NXI.0000000000200077
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author Hurtubise, Brigitte
Frohman, Elliot M.
Galetta, Steven
Balcer, Laura J.
Frohman, Teresa C.
Lisak, Robert P.
Newsome, Scott D.
Graves, Jennifer S.
Zamvil, Scott S.
Amezcua, Lilyana
author_facet Hurtubise, Brigitte
Frohman, Elliot M.
Galetta, Steven
Balcer, Laura J.
Frohman, Teresa C.
Lisak, Robert P.
Newsome, Scott D.
Graves, Jennifer S.
Zamvil, Scott S.
Amezcua, Lilyana
author_sort Hurtubise, Brigitte
collection PubMed
description Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult.
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spelling pubmed-97532852022-12-15 MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings Hurtubise, Brigitte Frohman, Elliot M. Galetta, Steven Balcer, Laura J. Frohman, Teresa C. Lisak, Robert P. Newsome, Scott D. Graves, Jennifer S. Zamvil, Scott S. Amezcua, Lilyana Neurol Neuroimmunol Neuroinflamm Diagnostic & Treatment Challenges Myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell–dependent antibody isotype, immunologic mechanisms of this disease are not fully understood. Thymic hyperplasia can be associated with certain autoimmune diseases. In this report we describe a case of MOGAD associated with thymic hyperplasia in a young adult. Lippincott Williams & Wilkins 2022-12-14 /pmc/articles/PMC9753285/ /pubmed/36517233 http://dx.doi.org/10.1212/NXI.0000000000200077 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Diagnostic & Treatment Challenges
Hurtubise, Brigitte
Frohman, Elliot M.
Galetta, Steven
Balcer, Laura J.
Frohman, Teresa C.
Lisak, Robert P.
Newsome, Scott D.
Graves, Jennifer S.
Zamvil, Scott S.
Amezcua, Lilyana
MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title_full MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title_fullStr MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title_full_unstemmed MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title_short MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
title_sort mog antibody–associated disease and thymic hyperplasia: from the national multiple sclerosis society case conference proceedings
topic Diagnostic & Treatment Challenges
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753285/
https://www.ncbi.nlm.nih.gov/pubmed/36517233
http://dx.doi.org/10.1212/NXI.0000000000200077
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