RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma

RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the prognostic impact of RASAL3 and the relationship with immune cell...

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Detalles Bibliográficos
Autores principales: Liang, Mei, Meng, Xiangzhi, Zhou, Boxuan, Gao, Yushun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753442/
https://www.ncbi.nlm.nih.gov/pubmed/36420686
http://dx.doi.org/10.1111/jcmm.17625
Descripción
Sumario:RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the prognostic impact of RASAL3 and the relationship with immune cell infiltration. RASAL3 expression in LUAD tissues was considerably low, with high RASAL3 expression associated with better overall survival, whereas the low expression was linked to advanced T, N, M classifications, TNM stage and lower grade. Furthermore, RASAL3 expression positively correlated with CD8+ T lymphocyte infiltration. In conclusion, RASAL3 expression is a potential prognostic and immunological biomarker of LUAD.

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