RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma

RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the prognostic impact of RASAL3 and the relationship with immune cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Mei, Meng, Xiangzhi, Zhou, Boxuan, Gao, Yushun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753442/
https://www.ncbi.nlm.nih.gov/pubmed/36420686
http://dx.doi.org/10.1111/jcmm.17625
_version_ 1784850963868155904
author Liang, Mei
Meng, Xiangzhi
Zhou, Boxuan
Gao, Yushun
author_facet Liang, Mei
Meng, Xiangzhi
Zhou, Boxuan
Gao, Yushun
author_sort Liang, Mei
collection PubMed
description RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the prognostic impact of RASAL3 and the relationship with immune cell infiltration. RASAL3 expression in LUAD tissues was considerably low, with high RASAL3 expression associated with better overall survival, whereas the low expression was linked to advanced T, N, M classifications, TNM stage and lower grade. Furthermore, RASAL3 expression positively correlated with CD8+ T lymphocyte infiltration. In conclusion, RASAL3 expression is a potential prognostic and immunological biomarker of LUAD.
format Online
Article
Text
id pubmed-9753442
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-97534422022-12-19 RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma Liang, Mei Meng, Xiangzhi Zhou, Boxuan Gao, Yushun J Cell Mol Med Original Articles RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the prognostic impact of RASAL3 and the relationship with immune cell infiltration. RASAL3 expression in LUAD tissues was considerably low, with high RASAL3 expression associated with better overall survival, whereas the low expression was linked to advanced T, N, M classifications, TNM stage and lower grade. Furthermore, RASAL3 expression positively correlated with CD8+ T lymphocyte infiltration. In conclusion, RASAL3 expression is a potential prognostic and immunological biomarker of LUAD. John Wiley and Sons Inc. 2022-11-24 2022-12 /pmc/articles/PMC9753442/ /pubmed/36420686 http://dx.doi.org/10.1111/jcmm.17625 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Liang, Mei
Meng, Xiangzhi
Zhou, Boxuan
Gao, Yushun
RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title_full RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title_fullStr RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title_full_unstemmed RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title_short RASAL3 predicts overall survival and CD8+ T lymphocyte infiltration in lung adenocarcinoma
title_sort rasal3 predicts overall survival and cd8+ t lymphocyte infiltration in lung adenocarcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753442/
https://www.ncbi.nlm.nih.gov/pubmed/36420686
http://dx.doi.org/10.1111/jcmm.17625
work_keys_str_mv AT liangmei rasal3predictsoverallsurvivalandcd8tlymphocyteinfiltrationinlungadenocarcinoma
AT mengxiangzhi rasal3predictsoverallsurvivalandcd8tlymphocyteinfiltrationinlungadenocarcinoma
AT zhouboxuan rasal3predictsoverallsurvivalandcd8tlymphocyteinfiltrationinlungadenocarcinoma
AT gaoyushun rasal3predictsoverallsurvivalandcd8tlymphocyteinfiltrationinlungadenocarcinoma

Ejemplares similares