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Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions

Post-COVID-19 conditions, also known as “long COVID”, has significantly impacted the lives of many individuals, but the risk factors for this condition are poorly understood. In this study, we performed a retrospective EHR analysis of 89,843 individuals at a multi-state health system in the United S...

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Autores principales: Ghosh, Pritha, Niesen, Michiel J.M., Pawlowski, Colin, Bandi, Hari, Yoo, Unice, Lenehan, Patrick J., M., Praveen Kumar, Nadig, Mihika, Ross, Jason, Ardhanari, Sankar, O’Horo, John C., Venkatakrishnan, AJ, Rosen, Clifford J., Telenti, Amalio, Hurt, Ryan T., Soundararajan, Venky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753786/
https://www.ncbi.nlm.nih.gov/pubmed/36523407
http://dx.doi.org/10.1101/2022.11.30.22282831
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author Ghosh, Pritha
Niesen, Michiel J.M.
Pawlowski, Colin
Bandi, Hari
Yoo, Unice
Lenehan, Patrick J.
M., Praveen Kumar
Nadig, Mihika
Ross, Jason
Ardhanari, Sankar
O’Horo, John C.
Venkatakrishnan, AJ
Rosen, Clifford J.
Telenti, Amalio
Hurt, Ryan T.
Soundararajan, Venky
author_facet Ghosh, Pritha
Niesen, Michiel J.M.
Pawlowski, Colin
Bandi, Hari
Yoo, Unice
Lenehan, Patrick J.
M., Praveen Kumar
Nadig, Mihika
Ross, Jason
Ardhanari, Sankar
O’Horo, John C.
Venkatakrishnan, AJ
Rosen, Clifford J.
Telenti, Amalio
Hurt, Ryan T.
Soundararajan, Venky
author_sort Ghosh, Pritha
collection PubMed
description Post-COVID-19 conditions, also known as “long COVID”, has significantly impacted the lives of many individuals, but the risk factors for this condition are poorly understood. In this study, we performed a retrospective EHR analysis of 89,843 individuals at a multi-state health system in the United States with PCR-confirmed COVID-19, including 1,086 patients diagnosed with long COVID and 1,086 matched controls not diagnosed with long COVID. For these two cohorts, we evaluated a wide range of clinical covariates, including laboratory tests, medication orders, phenotypes recorded in the clinical notes, and outcomes. We found that chronic pulmonary disease (CPD) was significantly more common as a pre-existing condition for the long COVID cohort than the control cohort (odds ratio: 1.9, 95% CI: [1.5, 2.6]). Additionally, long-COVID patients were more likely to have a history of migraine (odds ratio: 2.2, 95% CI: [1.6, 3.1]) and fibromyalgia (odds ratio: 2.3, 95% CI: [1.3, 3.8]). During the acute infection phase, the following lab measurements were abnormal in the long COVID cohort: high triglycerides (mean(longCOVID): 278.5 mg/dL vs. mean(control): 141.4 mg/dL), low HDL cholesterol levels (mean(longCOVID): 38.4 mg/dL vs. mean(control): 52.5 mg/dL), and high neutrophil-lymphocyte ratio (mean(longCOVID): 10.7 vs. mean(control): 7.2). The hospitalization rate during the acute infection phase was also higher in the long COVID cohort compared to the control cohort (rate(longCOVID): 5% vs. rate(control): 1%). Overall, this study suggests that the severity of acute infection and a history of CPD, migraine, CFS, or fibromyalgia may be risk factors for long COVID symptoms. Our findings motivate clinical studies to evaluate whether suppressing acute disease severity proactively, especially in patients at high risk, can reduce incidence of long COVID.
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spelling pubmed-97537862022-12-16 Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions Ghosh, Pritha Niesen, Michiel J.M. Pawlowski, Colin Bandi, Hari Yoo, Unice Lenehan, Patrick J. M., Praveen Kumar Nadig, Mihika Ross, Jason Ardhanari, Sankar O’Horo, John C. Venkatakrishnan, AJ Rosen, Clifford J. Telenti, Amalio Hurt, Ryan T. Soundararajan, Venky medRxiv Article Post-COVID-19 conditions, also known as “long COVID”, has significantly impacted the lives of many individuals, but the risk factors for this condition are poorly understood. In this study, we performed a retrospective EHR analysis of 89,843 individuals at a multi-state health system in the United States with PCR-confirmed COVID-19, including 1,086 patients diagnosed with long COVID and 1,086 matched controls not diagnosed with long COVID. For these two cohorts, we evaluated a wide range of clinical covariates, including laboratory tests, medication orders, phenotypes recorded in the clinical notes, and outcomes. We found that chronic pulmonary disease (CPD) was significantly more common as a pre-existing condition for the long COVID cohort than the control cohort (odds ratio: 1.9, 95% CI: [1.5, 2.6]). Additionally, long-COVID patients were more likely to have a history of migraine (odds ratio: 2.2, 95% CI: [1.6, 3.1]) and fibromyalgia (odds ratio: 2.3, 95% CI: [1.3, 3.8]). During the acute infection phase, the following lab measurements were abnormal in the long COVID cohort: high triglycerides (mean(longCOVID): 278.5 mg/dL vs. mean(control): 141.4 mg/dL), low HDL cholesterol levels (mean(longCOVID): 38.4 mg/dL vs. mean(control): 52.5 mg/dL), and high neutrophil-lymphocyte ratio (mean(longCOVID): 10.7 vs. mean(control): 7.2). The hospitalization rate during the acute infection phase was also higher in the long COVID cohort compared to the control cohort (rate(longCOVID): 5% vs. rate(control): 1%). Overall, this study suggests that the severity of acute infection and a history of CPD, migraine, CFS, or fibromyalgia may be risk factors for long COVID symptoms. Our findings motivate clinical studies to evaluate whether suppressing acute disease severity proactively, especially in patients at high risk, can reduce incidence of long COVID. Cold Spring Harbor Laboratory 2022-12-01 /pmc/articles/PMC9753786/ /pubmed/36523407 http://dx.doi.org/10.1101/2022.11.30.22282831 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Ghosh, Pritha
Niesen, Michiel J.M.
Pawlowski, Colin
Bandi, Hari
Yoo, Unice
Lenehan, Patrick J.
M., Praveen Kumar
Nadig, Mihika
Ross, Jason
Ardhanari, Sankar
O’Horo, John C.
Venkatakrishnan, AJ
Rosen, Clifford J.
Telenti, Amalio
Hurt, Ryan T.
Soundararajan, Venky
Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title_full Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title_fullStr Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title_full_unstemmed Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title_short Severe acute infection and chronic pulmonary disease are risk factors for developing post-COVID-19 conditions
title_sort severe acute infection and chronic pulmonary disease are risk factors for developing post-covid-19 conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753786/
https://www.ncbi.nlm.nih.gov/pubmed/36523407
http://dx.doi.org/10.1101/2022.11.30.22282831
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