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Adiponectin: a pleiotropic hormone with multifaceted roles

Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologic...

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Autores principales: Shklyaev, S. S., Melnichenko, G. A., Volevodz, N. N., Falaleeva, N. A., Ivanov, S. A., Kaprin, A. D., Mokrysheva, N. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrinology Research Centre 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753852/
https://www.ncbi.nlm.nih.gov/pubmed/35018766
http://dx.doi.org/10.14341/probl12827
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author Shklyaev, S. S.
Melnichenko, G. A.
Volevodz, N. N.
Falaleeva, N. A.
Ivanov, S. A.
Kaprin, A. D.
Mokrysheva, N. G.
author_facet Shklyaev, S. S.
Melnichenko, G. A.
Volevodz, N. N.
Falaleeva, N. A.
Ivanov, S. A.
Kaprin, A. D.
Mokrysheva, N. G.
author_sort Shklyaev, S. S.
collection PubMed
description Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states.
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spelling pubmed-97538522022-12-16 Adiponectin: a pleiotropic hormone with multifaceted roles Shklyaev, S. S. Melnichenko, G. A. Volevodz, N. N. Falaleeva, N. A. Ivanov, S. A. Kaprin, A. D. Mokrysheva, N. G. Probl Endokrinol (Mosk) Research Article Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states. Endocrinology Research Centre 2021-12-30 /pmc/articles/PMC9753852/ /pubmed/35018766 http://dx.doi.org/10.14341/probl12827 Text en Copyright © Endocrinology Research Centre, 2021 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License.
spellingShingle Research Article
Shklyaev, S. S.
Melnichenko, G. A.
Volevodz, N. N.
Falaleeva, N. A.
Ivanov, S. A.
Kaprin, A. D.
Mokrysheva, N. G.
Adiponectin: a pleiotropic hormone with multifaceted roles
title Adiponectin: a pleiotropic hormone with multifaceted roles
title_full Adiponectin: a pleiotropic hormone with multifaceted roles
title_fullStr Adiponectin: a pleiotropic hormone with multifaceted roles
title_full_unstemmed Adiponectin: a pleiotropic hormone with multifaceted roles
title_short Adiponectin: a pleiotropic hormone with multifaceted roles
title_sort adiponectin: a pleiotropic hormone with multifaceted roles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753852/
https://www.ncbi.nlm.nih.gov/pubmed/35018766
http://dx.doi.org/10.14341/probl12827
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