Cargando…
Adiponectin: a pleiotropic hormone with multifaceted roles
Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologic...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrinology Research Centre
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753852/ https://www.ncbi.nlm.nih.gov/pubmed/35018766 http://dx.doi.org/10.14341/probl12827 |
_version_ | 1784851057124311040 |
---|---|
author | Shklyaev, S. S. Melnichenko, G. A. Volevodz, N. N. Falaleeva, N. A. Ivanov, S. A. Kaprin, A. D. Mokrysheva, N. G. |
author_facet | Shklyaev, S. S. Melnichenko, G. A. Volevodz, N. N. Falaleeva, N. A. Ivanov, S. A. Kaprin, A. D. Mokrysheva, N. G. |
author_sort | Shklyaev, S. S. |
collection | PubMed |
description | Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states. |
format | Online Article Text |
id | pubmed-9753852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Endocrinology Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-97538522022-12-16 Adiponectin: a pleiotropic hormone with multifaceted roles Shklyaev, S. S. Melnichenko, G. A. Volevodz, N. N. Falaleeva, N. A. Ivanov, S. A. Kaprin, A. D. Mokrysheva, N. G. Probl Endokrinol (Mosk) Research Article Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states. Endocrinology Research Centre 2021-12-30 /pmc/articles/PMC9753852/ /pubmed/35018766 http://dx.doi.org/10.14341/probl12827 Text en Copyright © Endocrinology Research Centre, 2021 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. |
spellingShingle | Research Article Shklyaev, S. S. Melnichenko, G. A. Volevodz, N. N. Falaleeva, N. A. Ivanov, S. A. Kaprin, A. D. Mokrysheva, N. G. Adiponectin: a pleiotropic hormone with multifaceted roles |
title | Adiponectin: a pleiotropic hormone with multifaceted roles |
title_full | Adiponectin: a pleiotropic hormone with multifaceted roles |
title_fullStr | Adiponectin: a pleiotropic hormone with multifaceted roles |
title_full_unstemmed | Adiponectin: a pleiotropic hormone with multifaceted roles |
title_short | Adiponectin: a pleiotropic hormone with multifaceted roles |
title_sort | adiponectin: a pleiotropic hormone with multifaceted roles |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753852/ https://www.ncbi.nlm.nih.gov/pubmed/35018766 http://dx.doi.org/10.14341/probl12827 |
work_keys_str_mv | AT shklyaevss adiponectinapleiotropichormonewithmultifacetedroles AT melnichenkoga adiponectinapleiotropichormonewithmultifacetedroles AT volevodznn adiponectinapleiotropichormonewithmultifacetedroles AT falaleevana adiponectinapleiotropichormonewithmultifacetedroles AT ivanovsa adiponectinapleiotropichormonewithmultifacetedroles AT kaprinad adiponectinapleiotropichormonewithmultifacetedroles AT mokryshevang adiponectinapleiotropichormonewithmultifacetedroles |