Cargando…

Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China

AIMS: Neonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows. ME...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Qingzhi, Zou, Hui, Zhang, Shuping, Lin, Jiujing, Nie, Wenying, Cui, Yazhou, Liu, Sijin, Han, Jinxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753981/
https://www.ncbi.nlm.nih.gov/pubmed/36531456
http://dx.doi.org/10.3389/fendo.2022.1052836
_version_ 1784851086705688576
author Hou, Qingzhi
Zou, Hui
Zhang, Shuping
Lin, Jiujing
Nie, Wenying
Cui, Yazhou
Liu, Sijin
Han, Jinxiang
author_facet Hou, Qingzhi
Zou, Hui
Zhang, Shuping
Lin, Jiujing
Nie, Wenying
Cui, Yazhou
Liu, Sijin
Han, Jinxiang
author_sort Hou, Qingzhi
collection PubMed
description AIMS: Neonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows. METHODS: Pregnant women were recruited in Jinan Maternity and Child Care Hospital and followed up until delivery. Multivariate generalized linear regression models (GLMs) and restricted cubic spline (RCS) regression analysis models were used to investigate the associations of maternal TSH and FT4 with neonatal metabolites. RESULTS: In total, 6,653 pairs of mothers and newborns were enrolled in our study. We identified 5 neonatal metabolites, including arginine/ornithine (Arg/Orn), C14:1/C2, C18:1, C3DC+C4OH and C8:1, that were significantly associated with maternal serum TSH during the whole pregnancy (P < 0.05), especially in the first trimester. Moreover, 10 neonatal metabolites were significantly associated with maternal serum FT4 (P < 0.05), most of which had positive correlations with maternal FT4 in the first trimester (P < 0.05). Some neonatal metabolites also had linear or nonlinear dose-effect relationships with maternal serum TSH and FT4 during the whole pregnancy, particularly in the first trimester. CONCLUSIONS: Our study, for the first time, provides epidemiological evidence that maternal serum TSH and FT4, especially during the first trimester, are associated with linear or nonlinear variations in neonatal metabolites. Efforts to identify newborn metabolism levels should carefully consider the effects of maternal thyroid function.
format Online
Article
Text
id pubmed-9753981
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97539812022-12-16 Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China Hou, Qingzhi Zou, Hui Zhang, Shuping Lin, Jiujing Nie, Wenying Cui, Yazhou Liu, Sijin Han, Jinxiang Front Endocrinol (Lausanne) Endocrinology AIMS: Neonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows. METHODS: Pregnant women were recruited in Jinan Maternity and Child Care Hospital and followed up until delivery. Multivariate generalized linear regression models (GLMs) and restricted cubic spline (RCS) regression analysis models were used to investigate the associations of maternal TSH and FT4 with neonatal metabolites. RESULTS: In total, 6,653 pairs of mothers and newborns were enrolled in our study. We identified 5 neonatal metabolites, including arginine/ornithine (Arg/Orn), C14:1/C2, C18:1, C3DC+C4OH and C8:1, that were significantly associated with maternal serum TSH during the whole pregnancy (P < 0.05), especially in the first trimester. Moreover, 10 neonatal metabolites were significantly associated with maternal serum FT4 (P < 0.05), most of which had positive correlations with maternal FT4 in the first trimester (P < 0.05). Some neonatal metabolites also had linear or nonlinear dose-effect relationships with maternal serum TSH and FT4 during the whole pregnancy, particularly in the first trimester. CONCLUSIONS: Our study, for the first time, provides epidemiological evidence that maternal serum TSH and FT4, especially during the first trimester, are associated with linear or nonlinear variations in neonatal metabolites. Efforts to identify newborn metabolism levels should carefully consider the effects of maternal thyroid function. Frontiers Media S.A. 2022-12-01 /pmc/articles/PMC9753981/ /pubmed/36531456 http://dx.doi.org/10.3389/fendo.2022.1052836 Text en Copyright © 2022 Hou, Zou, Zhang, Lin, Nie, Cui, Liu and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hou, Qingzhi
Zou, Hui
Zhang, Shuping
Lin, Jiujing
Nie, Wenying
Cui, Yazhou
Liu, Sijin
Han, Jinxiang
Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title_full Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title_fullStr Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title_full_unstemmed Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title_short Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
title_sort association of maternal tsh and neonatal metabolism: a large prospective cohort study in china
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753981/
https://www.ncbi.nlm.nih.gov/pubmed/36531456
http://dx.doi.org/10.3389/fendo.2022.1052836
work_keys_str_mv AT houqingzhi associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT zouhui associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT zhangshuping associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT linjiujing associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT niewenying associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT cuiyazhou associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT liusijin associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina
AT hanjinxiang associationofmaternaltshandneonatalmetabolismalargeprospectivecohortstudyinchina