3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sensitivities are lacking. We developed an organoid-b...

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Detalles Bibliográficos
Autores principales: Kang, Ya’an, Deng, Jenying, Ling, Jianhua, Li, Xinqun, Chiang, Yi-Ju, Koay, Eugene J., Wang, Huamin, Burks, Jared K., Chiao, Paul J., Hurd, Mark W., Bhutani, Manoop S., Lee, Jeffrey H., Weston, Brian R., Maitra, Anirban, Ikoma, Naruhiko, Tzeng, Ching-Wei D., Lee, Jeffrey E., DePinho, Ronald A., Wolff, Robert A., Pant, Shubham, McAllister, Florencia, Katz, Matthew H.G., Fleming, Jason B., Kim, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753992/
https://www.ncbi.nlm.nih.gov/pubmed/36282600
http://dx.doi.org/10.1172/JCI151604

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