A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas

Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (TFs) including FOXO1, EBF1, PAX5, and IRF4 that ar...

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Detalles Bibliográficos
Autores principales: Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J., Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V., Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V., Cantley, Lewis C., Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A., Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753996/
https://www.ncbi.nlm.nih.gov/pubmed/36282572
http://dx.doi.org/10.1172/JCI160767

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