Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a dysregulated urea cycle is implicated in cancer development, the impact of GS’s ammonia clearance function has not b...

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Detalles Bibliográficos
Autores principales: Dai, Weiwei, Shen, Jianliang, Yan, Junrong, Bott, Alex J., Maimouni, Sara, Daguplo, Heineken Q., Wang, Yujue, Khayati, Khoosheh, Guo, Jessie Yanxiang, Zhang, Lanjing, Wang, Yongbo, Valvezan, Alexander, Ding, Wen-Xing, Chen, Xin, Su, Xiaoyang, Gao, Shenglan, Zong, Wei-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754002/
https://www.ncbi.nlm.nih.gov/pubmed/36256480
http://dx.doi.org/10.1172/JCI161408

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