Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals

As a highly regenerative organ, the intestine is a promising source for cellular reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells can be converted to insulin-producing cells by forkhead box O1 (FoxO1) ablation, but their numbers are limited. In this study,...

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Detalles Bibliográficos
Autores principales: Du, Wen, Wang, Junqiang, Kuo, Taiyi, Wang, Liheng, McKimpson, Wendy M., Son, Jinsook, Watanabe, Hitoshi, Kitamoto, Takumi, Lee, Yunkyoung, Creusot, Remi J., Ratner, Lloyd E., McCune, Kasi, Chen, Ya-Wen, Grubbs, Brendan H., Thornton, Matthew E., Fan, Jason, Sultana, Nishat, Diaz, Bryan S., Balasubramanian, Iyshwarya, Gao, Nan, Belvedere, Sandro, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754100/
https://www.ncbi.nlm.nih.gov/pubmed/36282594
http://dx.doi.org/10.1172/JCI162720

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