Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success. Here, we report a humanized IgG1 mAb, namely JS007, with high binding affinity...

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Detalles Bibliográficos
Autores principales: Guan, Jiawei, Liu, Hongchuan, Chai, Yan, Yu, Jie, Yao, Jian, Wang, Jing, Pan, Zhiwei, Zhang, Jing, Zhou, Yuehua, Liu, Hui, Yao, Sheng, Qi, Jianxun, Feng, Hui, Gao, George F., Wang, Qihui, Shi, Yi, Tan, Shuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754112/
https://www.ncbi.nlm.nih.gov/pubmed/36511654
http://dx.doi.org/10.1080/19420862.2022.2153409

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